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Second cancers and Richter transformation are the leading causes of death in patients with trisomy 12 chronic lymphocytic leukemia.

Author: AbruzzoLynne V, FerrajoliAlessandra, KeatingMichael J, O'BrienSusan, StratiPaolo, WierdaWilliam G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Patients with trisomy 12 (+12) chronic lymphocytic leukemia (CLL) showed a higher incidence of thrombocytopenia, Richter transformation, and second malignant neoplasms (SMN), in addition to the expected increased rate of CD38 positivity and atypical immunophenotype.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Trisomy 12 (+12) is detected by fluorescence in-situ hybridization (FISH) analysis in up to 20% of patients with chronic lymphocytic leukemia (CLL). Patients with +12 are known to have unique features and to carry an intermediate prognosis. PATIENTS AND METHODS: In order to better defin...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/25800543

データ提供：米国国立医学図書館（NLM）

The Shifting Sands of Trisomy 12 CLL: Understanding Prognosis and Challenges

The world of chronic lymphocytic leukemia (CLL) is a vast and intricate desert, with unique challenges for each patient. This study focuses on the subset of patients with trisomy 12 (+12) CLL, exploring their clinical characteristics, prognosis, and treatment outcomes. The authors meticulously analyzed data from a large cohort of patients with +12 CLL, aiming to better understand this specific subtype and identify potential risk factors for disease progression and treatment failure.

Mapping the Desert: Characteristics and Prognosis of Trisomy 12 CLL

The study revealed that patients with +12 CLL exhibit distinct clinical and biological features, including a higher incidence of thrombocytopenia, Richter transformation, and second malignant neoplasms (SMN). This is like discovering a unique oasis in the desert, with its own distinct flora and fauna. The findings highlight the need for close monitoring and tailored management approaches for patients with +12 CLL.

Navigating the Oasis: Monitoring and Management of Trisomy 12 CLL

The study underscores the importance of regular surveillance for second cancers in patients with +12 CLL. It also highlights the need for individualized treatment strategies, considering the unique features of this subtype and potential risk factors for disease progression. This is akin to understanding the specific challenges and opportunities of each oasis in the desert, allowing for a more informed and effective approach to navigating the landscape.

Dr. Camel's Conclusion

This study serves as a reminder that within the vast desert of CLL, distinct oases exist, each with its own characteristics and challenges. By understanding the unique features of +12 CLL and employing individualized treatment strategies, we can navigate this challenging terrain and provide the best possible care for patients.

Date :
  1. Date Completed 2016-03-24
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

25800543

DOI: Digital Object Identifier

NIHMS773729

Related Literature

Article Analysis
・Causes of chronic lymphocytic leukemia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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