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Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S-Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes.
Author: BreitholtzKatarina, DarnellMalin, IsinEmre M, JurvaUlrik, WeidolfLars
Original Abstract of the Article :
Xenobiotic carboxylic acids may be metabolized to oxidative metabolites, acyl glucuronides, and/or S-acyl-CoA thioesters (CoA conjugates) in vitro, e.g., in hepatocytes, and in vivo. These metabolites can potentially be reactive species and bind covalently to tissue proteins and are generally consid...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1021/tx500514z
データ提供：米国国立医学図書館（NLM）
Xenobiotic Carboxylic Acids: A Desert of Reactive Metabolites
In the vast desert of drug metabolism research, we often encounter the challenge of understanding how our bodies process and eliminate foreign substances. This study investigates the covalent binding of different metabolites formed from xenobiotic carboxylic acids, focusing on the reactivity of acyl glucuronides and S-acyl-CoA thioesters. It's like exploring a desert, where the interplay of different elements can lead to unexpected reactions.
Covalent Binding: A Potential Source of Toxicity
The study reveals that drug-CoA conjugates, often overlooked in the past, can be significantly more reactive than their corresponding oxidative metabolites and acyl glucuronides. This finding is like discovering a hidden oasis in the desert, where the seemingly innocuous can harbor a hidden danger. It emphasizes the importance of considering the reactivity of different metabolites in assessing drug safety and potential for adverse effects.
Drug Safety: A Desert of Careful Navigation
This research highlights the importance of understanding the reactivity of different metabolites in drug development and safety assessments. It's like navigating a desert, where knowledge of the terrain is crucial to avoiding potential hazards. By carefully considering the reactivity of different metabolites, we can develop safer and more effective drugs, ensuring that patients receive the best possible care.
Dr. Camel's Conclusion
This research delves into the complex world of drug metabolism, highlighting the importance of understanding the reactivity of different metabolites in drug development and safety assessments. It's a reminder that even in the seemingly barren desert of drug research, hidden dangers can lurk, emphasizing the need for rigorous research and careful navigation to ensure patient safety.
Date :
- Date Completed 2016-02-10
- Date Revised 2015-05-18
Further Info :
Related Literature
English
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