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Acute Effects of Muscarinic M1 Receptor Modulation on AβPP Metabolism and Amyloid-β Levels in vivo: A Microdialysis Study.

Author: ChadhaAntonella Santuccione, FisherAbraham, HoeySarah E, KulicLuka, McAfooseJordan, NitschRoger M, SpäniClaudia, WeltTobias

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Acute stimulation of muscarinic M1 receptors in AβPP transgenic mice rapidly reduces interstitial fluid (ISF) amyloid-β (Aβ) levels by shifting AβPP processing towards the non-amyloidogenic pathway. This finding suggests that selective muscarinic M1 receptor agonists may be a promising therapeutic approach for Alzheimer's disease (AD).
Paper Details　
Original Abstract of the Article :
Indirect modulation of cholinergic activity by cholinesterase inhibition is currently a widely established symptomatic treatment for Alzheimer's disease (AD). Selective activation of certain muscarinic receptor subtypes has emerged as an alternative cholinergic-based amyloid-lowering strategy for AD...See full text at original site
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引用元：
https://doi.org/10.3233/JAD-150152

データ提供：米国国立医学図書館（NLM）

Alzheimer's Disease: Seeking a New Oasis in the Desert of Memory Loss

The search for treatments for [Alzheimer's disease (AD)] is a continuous journey, like a nomad searching for a hidden oasis in a vast and unforgiving desert. This study explores the potential of [muscarinic M1 receptor modulation] to reduce [amyloid-β (Aβ) levels] in the brain. The researchers investigated the acute effects of [M1 receptor modulation] on [AβPP metabolism] in [AβPP transgenic mice].

The Results: A Glimpse of a Potential Oasis

The study found that [stimulating M1 receptors] resulted in a [rapid reduction] of [Aβ levels] in the brain. This is like finding a small, hidden oasis in the desert, offering a temporary respite from the harsh conditions. The study also revealed that [M1 receptor modulation] influenced the [processing of amyloid-β protein precursor (AβPP)], shifting it towards a [non-amyloidogenic pathway].

What Does This Mean for Us?

These findings suggest that [muscarinic M1 receptors] play a crucial role in [Aβ production] and that [M1 receptor modulation] might be a promising therapeutic strategy for [AD]. It's like discovering a new water source in the desert - it offers hope for a better future, but further exploration is needed to ensure its long-term viability.

Dr.Camel's Conclusion

This study offers a glimmer of hope in the fight against [AD], revealing a potential oasis in the desert of memory loss. While further research is needed to fully explore the possibilities, it's a reminder that even in the most challenging landscapes, there are opportunities for discovery and progress.

Date :
  1. Date Completed 2016-06-30
  2. Date Revised 2015-09-25
Further Info :

Pubmed ID

25881909

DOI: Digital Object Identifier

10.3233/JAD-150152

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Languages

English

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