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Differential effects of viremia and microbial translocation on immune activation in HIV-infected patients throughout ritonavir-boosted darunavir monotherapy.

Author: BenMarzouk-HidalgoOmar J, Gutiérrez-ValenciaAlicia, López-CortésLuis F, Ruiz-ValderasRosa, Torres-CornejoAlmudena, VicianaPompeyo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the role of microbial translocation (MT) in CD4 and CD8 T cells immune activation (IA) in HIV-1-infected patients on ritonavir-boosted darunavir monotherapy (mtDRV/rtv). Results show that MT does not have a pivotal role in T-cell activation in patients with long-term viral suppression.
Paper Details　
Original Abstract of the Article :
The purpose of this article is to evaluate the evolution of microbial translocation (MT) and its role in CD4 and CD8 T cells immune activation (IA) in HIV-1-infected patients on ritonavir-boosted darunavir monotherapy (mtDRV/rtv).Prospective study of consecutive HIV-1-infected patients switched to m...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603072/

データ提供：米国国立医学図書館（NLM）

Viremia and Microbial Translocation: Unraveling the Immune Response in HIV

This research explores the intricate interplay between viremia, microbial translocation, and immune activation in HIV-infected individuals receiving ritonavir-boosted darunavir monotherapy. The study analyzes the evolution of microbial translocation and its impact on CD4 and CD8 T-cell immune activation, identifying the factors that influence the immune response to HIV. The authors discovered that persistent viremia was the primary factor driving immune activation in these patients, while microbial translocation played a less significant role.

Viremia: A Driving Force Behind Immune Activation in HIV

This research highlights the dominant role of persistent viremia in driving immune activation in HIV-infected individuals. The study underscores the importance of achieving and maintaining sustained viral suppression in effectively managing HIV infection and preserving immune function. These findings emphasize the need for comprehensive and sustained antiviral therapies to control viremia and mitigate the impact on immune function.

Navigating HIV Treatment: A Quest for Sustained Viral Suppression

HIV treatment requires a multi-faceted approach, focusing on both managing viral load and preserving immune function. This research highlights the critical importance of achieving and maintaining sustained viral suppression in effectively managing HIV infection. It underscores the need for ongoing research to develop more effective and long-lasting antiviral therapies that can effectively control viremia and minimize the impact on the immune system.

Dr.Camel's Conclusion

This research explores the relationship between viremia, microbial translocation, and immune activation in HIV-infected individuals receiving ritonavir-boosted darunavir monotherapy. The study highlights the dominant role of persistent viremia in driving immune activation, emphasizing the importance of achieving and maintaining sustained viral suppression in effectively managing HIV infection and preserving immune function.
Date :
  1. Date Completed 2015-07-22
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

25929922

DOI: Digital Object Identifier

PMC4603072

Related Literature

Article Analysis
・Effects of darunavir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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