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D1 and D2 antagonists reverse the effects of appetite suppressants on weight loss, food intake, locomotion, and rebalance spiking inhibition in the rat NAc shell.

Author: EliasDavid, GutierrezRanier, KalyanasundarB, LunaAlvaro, MorenoMario G, PerezClaudia I, SimonSidney A, SolorioJessica

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the effects of appetite suppressants (diethylpropion, phentermine, and bupropion) on neuronal activity in the nucleus accumbens (NAc) shell, a brain region involved in feeding and motor activity. The study shows that these drugs modulate NAc shell activity and that dopamine antagonists can partially reverse these effects.
Paper Details　
Original Abstract of the Article :
Obesity is a worldwide health problem that has reached epidemic proportions. To ameliorate this problem, one approach is the use of appetite suppressants. These compounds are frequently amphetamine congeners such as diethylpropion (DEP), phentermine (PHEN), and bupropion (BUP), whose effects are med...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509405/

データ提供：米国国立医学図書館（NLM）

Dopamine's Role in Appetite Suppression

Obesity is a growing global concern, and researchers are constantly exploring new ways to combat this desert of excess weight. Appetite suppressants have emerged as a potential oasis, but understanding their mechanisms is crucial. This study investigated the role of dopamine in the effects of appetite suppressants, focusing on the nucleus accumbens (NAc) shell, a brain region involved in feeding and motor activity. The study found that appetite suppressants like diethylpropion (DEP), phentermine (PHEN), and bupropion (BUP) impact dopamine levels in the NAc shell, ultimately influencing weight loss, food intake, and movement.

Dopamine's Dance in the NAc Shell

These findings suggest that dopamine plays a crucial role in the effects of appetite suppressants, particularly in the NAc shell. The researchers observed that these drugs triggered a decrease in weight and food intake while increasing locomotion, potentially through dopamine-mediated pathways. It's like a delicate dance, where dopamine orchestrates the body's response to these appetite suppressants.

Navigating the Weight Loss Desert

This research offers valuable insight into how appetite suppressants work and highlights the importance of dopamine in this process. It's like discovering a hidden path through the desert of obesity - a path that may lead to a healthier future. Understanding the role of dopamine may pave the way for developing more targeted and effective strategies for weight management.

Dr.Camel's Conclusion

This study sheds light on the intricate interplay between dopamine and appetite suppressants, revealing their impact on weight loss, food intake, and movement. This research is like a map guiding us through the complexities of appetite regulation, helping us understand the mechanisms of weight management and potentially leading to more effective treatments.

Date :
  1. Date Completed 2016-03-28
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

25972577

DOI: Digital Object Identifier

PMC4509405

Related Literature

Article Analysis
・Effects of diethylpropion
SNS
PICO Info
in preparation
Languages

English

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