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Effects of formulation design on niacin therapeutics: mechanism of action, metabolism, and drug delivery.

Author: CooperDustin L, HarirforooshSam, MurrellDerek E, RoaneDavid S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Niacin is a lipid-regulating drug with significant side effects, including flushing and hepatic toxicity. This article discusses the various approaches to niacin delivery, such as transdermal formulations and polymeric micro/nanoparticle encapsulation, that have been explored to reduce these side effects.
Paper Details　
Original Abstract of the Article :
Niacin is a highly effective, lipid regulating drug associated with a number of metabolically induced side effects such as prostaglandin (PG) mediated flushing and hepatic toxicity. In an attempt to reduce the development of these adverse effects, scientists have investigated differing methods of ni...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijpharm.2015.05.024

データ提供：米国国立医学図書館（NLM）

Niacin Therapeutics: Navigating the Desert of Drug Delivery and Metabolism

The landscape of drug delivery and metabolism is a vast and complex desert, with researchers constantly seeking ways to improve drug efficacy and minimize side effects. This review focuses on niacin, a lipid-regulating drug with a number of metabolically induced side effects. The authors explore various formulation designs aimed at controlling drug release and altering metabolism, seeking to optimize niacin's therapeutic benefits while minimizing its adverse effects.

The Hidden Oases of Niacin Delivery

The review delves into the intricate world of niacin delivery, exploring the challenges and opportunities associated with different formulation approaches. From oral immediate release to sustained and extended release formulations, researchers have experimented with various strategies to optimize niacin's therapeutic potential. This research, like a careful exploration of a desert landscape, seeks to identify the most effective and safe pathways for delivering this valuable drug.

Navigating the Desert of Drug Development: A Journey of Innovation

The study underscores the ongoing quest for improved drug delivery systems, emphasizing the importance of innovative approaches to address the challenges of drug metabolism and side effects. The authors highlight the potential of alternative delivery methods, such as transdermal delivery and polymeric micro/nanoparticle encapsulation, offering a promising path forward in niacin therapeutics. This research, like the pursuit of a better route through a challenging desert, reflects the constant search for improved solutions in drug development.

Dr.Camel's Conclusion

This review offers a comprehensive overview of niacin therapeutics, highlighting the challenges and opportunities associated with its delivery and metabolism. Researchers continue to explore new and innovative strategies to optimize niacin's therapeutic benefits while minimizing its adverse effects. Just as a desert traveler seeks the most efficient and safe routes, scientists are constantly searching for better ways to deliver drugs, ensuring optimal outcomes for patients.

Date :
  1. Date Completed 2016-03-23
  2. Date Revised 2015-06-27
Further Info :

Pubmed ID

25987211

DOI: Digital Object Identifier

10.1016/j.ijpharm.2015.05.024

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・Side Effects of niacin
SNS
PICO Info
in preparation
Languages

English

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