Does elevation of serum creatinine in patients with chronic hepatitis C under therapy of telaprevir mean renal impairment?

Author: IkedaHiroki, Kamijo-IkemoriAtsuko, KimuraKenjiro, MatsuiKatsuomi, OkuseChiaki, ShibagakiYugo, SugayaTakeshi, YasudaTakashi

Paper Details 
Original Abstract of the Article :
AIM: Treatment with telaprevir (TVR) entails adverse side-effects including anaemia and elevation of serum creatinine (SCr) level. Our purpose was to evaluate the effects of treatment with TVR on renal function in adults with chronic hepatitis C. METHODS: Thirteen adult patients with HCV genotype 1...See full text at original site
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引用元:
https://doi.org/10.1111/nep.12517

データ提供:米国国立医学図書館(NLM)

Telaprevir: Navigating the Shifting Sands of Renal Function in Hepatitis C Patients

The treatment of chronic hepatitis C, like a treacherous desert journey, often presents challenges. This study, like a vigilant desert guide, examines the potential impact of telaprevir (TVR) on renal function in patients with chronic hepatitis C. The authors, armed with careful observation and scientific rigor, explore the relationship between TVR therapy and serum creatinine levels. Their findings, like a trail of footprints in the sand, provide valuable insights into the potential effects of this antiviral medication on renal health.

Telaprevir: A Complex Relationship with Renal Function

This study, like a desert oasis offering both respite and caution, reveals a complex relationship between telaprevir and renal function. While TVR therapy may lead to an increase in serum creatinine levels, this increase does not necessarily indicate renal impairment. The study suggests that TVR may inhibit creatinine secretion from the proximal tubules, leading to a temporary elevation in serum creatinine levels. Further investigation is needed to fully understand the long-term impact of TVR on renal function.

Telaprevir: A Call for Vigilance in Hepatitis C Treatment

This study, like a desert wind carrying whispers of caution, reminds us of the importance of careful monitoring and individualized care in patients with hepatitis C undergoing treatment. The potential impact of telaprevir on renal function necessitates vigilance and close observation of serum creatinine levels. By understanding these complex interactions, we can better ensure that patients receive safe and effective treatment.

Dr.Camel's Conclusion

The treatment of hepatitis C, like a vast and unforgiving desert, often requires careful navigation. This study's findings shed light on the intricate relationship between telaprevir and renal function, reminding us to tread cautiously and prioritize patient well-being.

Date :
  1. Date Completed 2016-04-12
  2. Date Revised 2015-10-07
Further Info :

Pubmed ID

25998031

DOI: Digital Object Identifier

10.1111/nep.12517

Related Literature

SNS
PICO Info
in preparation
Languages

English

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