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Update on Cardiovascular Safety of Tyrosine Kinase Inhibitors: With a Special Focus on QT Interval, Left Ventricular Dysfunction and Overall Risk/Benefit.

Author: MorganrothJoel, ShahRashmi R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This report provides an update on the cardiovascular safety of tyrosine kinase inhibitors (TKIs), a class of medications used to treat cancer. The report summarizes the potential risks of TKIs, including QT interval prolongation, left ventricular dysfunction, hypertension, and arterial thromboembolic events. The report emphasizes the need for effective pharmacovigilance and ongoing re-assessment of the risk-benefit profile of these agents.
Paper Details　
Original Abstract of the Article :
We previously reviewed the cardiovascular safety of 16 tyrosine kinase inhibitors (TKIs), approved for use in oncology as of 30 September 2012. Since then, the indications for some of them have been widened and an additional nine TKIs have also been approved as of 30 April 2015. Eight of these nine ...See full text at original site
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引用元：
https://doi.org/10.1007/s40264-015-0300-1

データ提供：米国国立医学図書館（NLM）

Cardiovascular Safety of Tyrosine Kinase Inhibitors

Tyrosine kinase inhibitors (TKIs), powerful drugs used to combat cancer, are like intrepid explorers venturing into the vast landscape of the human body. However, like any explorer, they must be carefully monitored to ensure they don't inadvertently cause unintended damage. This study reviews the cardiovascular safety of a wide range of TKIs, focusing on their potential to affect the heart's rhythm, its pumping function, and blood pressure. The authors highlight the importance of ongoing monitoring and careful evaluation of the risks and benefits of these medications.

Navigating the Risks and Benefits of TKIs

The study provides a comprehensive overview of the cardiovascular safety concerns associated with TKIs, emphasizing the importance of balancing the therapeutic benefits with potential risks to the heart. This information is crucial for doctors in making informed decisions about TKI use.

Understanding Potential Cardiovascular Risks

It's essential to be aware of the potential cardiovascular risks associated with TKIs. Regular monitoring and close communication with your doctor are key to managing these risks and ensuring the best possible treatment outcomes.

Dr.Camel's Conclusion

This study reminds us that even powerful tools can have unintended consequences. The careful monitoring and evaluation of TKIs are crucial to ensuring that their benefits outweigh their risks. It's a reminder that medicine is a journey of continuous learning and adaptation.
Date :
  1. Date Completed 2016-05-02
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

26008987

DOI: Digital Object Identifier

10.1007/s40264-015-0300-1

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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