Comparison of angiogenic and proliferative effects of three commonly used agents for pulmonary artery hypertension (sildenafil, iloprost, bosentan): is angiogenesis always beneficial?

Author: AvcuF, DoganciS, ErolG, KadanM, OzgurtasT, OzkanG, YesildalF, YildirimV

Paper Details 
Original Abstract of the Article :
Pulmonary artery hypertension (PAH) is devastating disease that has very serious outcomes. Dysregulated angiogenesis is one of the main responsible courses in pathophysiology of disease. Our experimental research intends to find out and compare the angiogenic effects of medications used sildenafil, ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/26044238

データ提供:米国国立医学図書館(NLM)

Angiogenesis in Pulmonary Artery Hypertension: Exploring the Complexities of Blood Vessel Growth

Pulmonary artery hypertension (PAH) is a complex and debilitating disease, characterized by abnormal blood vessel growth (angiogenesis). This research delves into the angiogenic effects of three commonly used medications for PAH: sildenafil, iloprost, and bosentan. The study aims to understand the nuances of angiogenesis in PAH and its implications for treatment strategies.

Unveiling the Secrets of Angiogenesis

The study found that while angiogenesis is often associated with beneficial effects, its role in PAH is complex and requires careful consideration. The researchers compared the angiogenic effects of three PAH medications, highlighting the potential for both positive and negative consequences associated with blood vessel growth. This research, like a desert explorer seeking out hidden oases, uncovers the intricate pathways of angiogenesis in PAH.

Navigating the Complexities of PAH Treatment

This research provides valuable insights into the complexities of angiogenesis in PAH and its implications for treatment. It reminds us that while angiogenesis can be beneficial in some circumstances, it can also contribute to the progression of PAH. This research, like a compass guiding us through a complex desert landscape, encourages a nuanced approach to treating PAH, taking into account the potential risks and benefits of angiogenic interventions.

Dr.Camel's Conclusion

The study provides a comprehensive analysis of the angiogenic effects of PAH medications, highlighting the complexities of blood vessel growth in this challenging disease. This research, like a sandstorm revealing the hidden intricacies of the desert, provides a deeper understanding of the multifaceted nature of PAH and its potential therapeutic targets.

Date :
  1. Date Completed 2016-01-15
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26044238

DOI: Digital Object Identifier

26044238

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English

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