Paper Details

  1. Home
  2. Paper Details

Evaluation of the Transwell System for Characterization of Dissolution Behavior of Inhalation Drugs: Effects of Membrane and Surfactant.

Author: BhagwatSharvari, BreitkreutzJörg, HochhausGünther, KrampeRaphael, MichlerVictoria, RohrschneiderMarc

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Validation StudyResearch to assess the validity and reliability of new measurement methods or diagnostic tests.

Overview

This study optimized a Transwell dissolution system for inhaled corticosteroids by incorporating faster equilibrating membranes and surfactant-containing dissolution medium. The optimized system allows for in vitro dissolution behavior to approximate in vivo absorption rates.
Paper Details　
Original Abstract of the Article :
Assessing the dissolution behavior of orally inhaled drug products (OIDs) has been proposed as an additional in vitro test for the characterization of innovator and generic drug development. A number of suggested dissolution methods (e.g., commercially available Transwell or Franz cell systems) have...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1021/acs.molpharmaceut.5b00221

データ提供：米国国立医学図書館（NLM）

Inhaled Drug Dissolution: Navigating the Desert of Drug Delivery

Delivering drugs to the lungs is like navigating a vast and intricate desert, a complex landscape with unique challenges. This study explores the dissolution behavior of inhaled drug products, seeking to optimize their delivery and absorption in the lungs.

Researchers investigated the use of Transwell systems for assessing the dissolution behavior of inhaled corticosteroids. They identified several potential pitfalls associated with this method and proposed modifications to improve its accuracy. This is like discovering that a traditional desert route might be inefficient and prone to obstacles, requiring a new path to be paved.

A Refined Approach to Inhaled Drug Delivery

The study suggests that the modified Transwell system offers a more reliable method for assessing the dissolution behavior of inhaled drugs. This is like finding a smoother and more direct route through the desert, leading to more efficient and predictable drug delivery.

Navigating the Desert of Drug Delivery: Seeking a Smoother Path

This research highlights the importance of optimizing drug delivery methods to enhance their effectiveness. It's like recognizing the need for a well-planned and well-maintained path to ensure a successful journey across the desert.

Dr.Camel's Conclusion

The study underscores the importance of continuous innovation in drug delivery. It's like finding new ways to harness the wind and sand to create a more efficient and sustainable journey across the desert. By embracing a rigorous and evidence-based approach, we can continue to improve the lives of patients by optimizing drug delivery and maximizing their therapeutic potential.

Date :
  1. Date Completed 2016-05-13
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

26091361

DOI: Digital Object Identifier

10.1021/acs.molpharmaceut.5b00221

Related Literature

Article Analysis
・Effects of ciclesonide oral inhalation
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.