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Modulating effects of leflunomide on the balance of Th17/Treg cells in collageninduced arthritis DBA/1 mice.
Author: HeQiang, LiXue-Liang, WangWei-Feng, XuQi, ZhuMing
Original Abstract of the Article :
To evaluated the effect and mechanism of leflunomide (LEF) in murine model of collage-induced arthritis (CIA) on modulating the balance of Th17/Treg cells. DBA mice were divided into: control, CIA, CIA + LEF and CIA + Ibuprofen group. After 14 days immunization with bovine type II collagen (CII), ex...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440017/
データ提供:米国国立医学図書館(NLM)
Leflunomide: A Potential Desert Oasis for Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease that can cause debilitating pain and joint damage. This study investigated the potential of a drug called leflunomide to treat RA by modulating the balance of immune cells called Th17 and Treg cells.
The researchers, like skilled desert guides, explored the complex landscape of the immune system, focusing on how leflunomide affected the balance of these key players. They found that leflunomide reduced the number of Th17 cells, which are known to promote inflammation, while it did not significantly impact Treg cells, which help to suppress inflammation. This is like creating a desert oasis by controlling the flow of water—leflunomide seems to be able to regulate the immune system by reducing the harmful effects of Th17 cells, creating a more balanced and peaceful environment within the body.
Leflunomide: A Potential New Tool for Rheumatoid Arthritis Treatment
The findings suggest that leflunomide could be a potential new treatment for RA, offering a different approach to managing the disease by targeting specific immune cells. This is like finding a new source of water in the desert—a promising discovery that could provide relief to those struggling with RA.
Managing Rheumatoid Arthritis: A Journey Through the Desert
Living with RA can be like navigating a harsh desert environment, with unpredictable storms and challenging terrain. This research provides hope that new medications, like leflunomide, could offer new strategies for managing this complex disease. By finding the right balance of treatment options, individuals with RA can journey through the desert of their condition with greater comfort and strength.
Dr.Camel's Conclusion
This study provides promising evidence for the potential of leflunomide to treat rheumatoid arthritis. By modulating the balance of specific immune cells, leflunomide could offer a new and effective approach to managing this chronic inflammatory disease. This research is a valuable step forward in the search for new treatments that can help individuals with RA navigate the challenges of their condition and live healthier, more fulfilling lives.
Date :
- Date Completed 2015-07-09
- Date Revised 2020-10-01
Further Info :
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