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Effect of erythromycin acistrate and erythromycin stearate on human colonic microflora.

Author: GordinA, Kaukoranta-TolvanenS S, MännistöP T, RenkonenO V, TammL

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Erythromycin acistrate and erythromycin stearate, both antibiotics, were compared for their effects on the faecal microflora in healthy volunteers. Both drugs induced similar changes, including suppression of gram-negative anaerobic and aerobic rods and an increase in enterococci.
Paper Details　
Original Abstract of the Article :
The effects of erythromycin acistrate (2'-acetyl erythromycin stearate), a new erythromycin derivative, and erythromycin stearate on the faecal microflora were compared in a randomized cross-over study. 12 healthy volunteers were given either drug 500 mg t.i.d. for 1 week. Their faeces were studied ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.3109/00365548909021702

データ提供：米国国立医学図書館（NLM）

Erythromycin: Impact on the Microbiome Desert

This research delves into the intricate world of the human gut microbiome, examining the impact of erythromycin acistrate and erythromycin stearate on its delicate ecosystem. The researchers conducted a randomized cross-over study to compare the effects of these two erythromycin derivatives on the faecal microflora of healthy volunteers.

A Journey Through the Microbiome Desert

The study revealed that both erythromycin derivatives induced significant changes in the composition of the gut microbiome, primarily suppressing the growth of gram-negative anaerobic and aerobic rods. While both drugs showed similar effects, they also highlighted the potential for altered resistance among staphylococci and enterococci.

Dr. Camel's Conclusion

This research underscores the significant impact of erythromycin on the gut microbiome, highlighting the need for careful consideration of its use and potential long-term effects. It serves as a reminder that the delicate ecosystem of the gut microbiome is vital to overall health and well-being.

Date :
  1. Date Completed 1990-03-14
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

2617212

DOI: Digital Object Identifier

10.3109/00365548909021702

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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