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Protriptyline treatment of sleep hypoxaemia in Duchenne muscular dystrophy.

Author: CalverleyP M, EdwardsR H, SmithP E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Protriptyline, an antidepressant, reduced REM sleep time in patients with Duchenne muscular dystrophy. While it also reduced sleep-related hypoxemia, its anticholinergic side effects limited its use for regular treatment.
Paper Details　
Original Abstract of the Article :
Protriptyline 20 mg daily reduced the total time spent in rapid eye movement sleep in an open study in four subjects with Duchenne muscular dystrophy. Sleep related hypoxaemia and episodes of desaturation were reduced. Anticholinergic side effects were prominent, however, in these patients, precludi...See full text at original site
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引用元：
https://doi.org/10.1136/thx.44.12.1002

データ提供：米国国立医学図書館（NLM）

Protriptyline: A Potential Treatment for Sleep Hypoxaemia in Duchenne Muscular Dystrophy

Duchenne muscular dystrophy (DMD) is a devastating genetic disorder that primarily affects boys. This study explores the potential of protriptyline, an antidepressant, to manage sleep-related breathing problems in DMD patients.

Protriptyline's Effect on Sleep Hypoxaemia

The study found that protriptyline reduced the amount of time spent in rapid eye movement (REM) sleep and decreased episodes of desaturation in DMD patients. However, the researchers also noted significant anticholinergic side effects, limiting its practical use for regular treatment.

Protriptyline's Effect on Sleep Hypoxaemia

This research, like a compass pointing toward a new direction in DMD treatment, provides valuable insights into potential approaches to managing sleep-related breathing problems.

Dr.Camel's Conclusion

This study is like a desert oasis offering a fleeting glimpse of hope. While protriptyline may hold promise for improving sleep in DMD patients, its side effects currently limit its practicality.
Date :
  1. Date Completed 1990-03-08
  2. Date Revised 2019-05-03
Further Info :

Pubmed ID

2617440

DOI: Digital Object Identifier

10.1136/thx.44.12.1002

Related Literature

Article Analysis
・Side Effects of protriptyline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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