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The effect of ketorolac tromethamine in reducing postoperative inflammation: double-mask parallel comparison with dexamethasone.

Author: AkersW A, FlachA J, JaffeN S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ketorolac, a nonsteroidal anti-inflammatory drug, was compared to dexamethasone in patients undergoing cataract surgery. Both drugs were equally effective in suppressing postoperative inflammation, with ketorolac demonstrating good tolerability and potential as a substitute for topical corticosteroids.
Paper Details　
Original Abstract of the Article :
Anterior chamber fluorophotometry was done after the oral administration of fluorescein sodium in patients undergoing extracapsular cataract extraction and posterior chamber intraocular lens insertion before and after surgery. The administration of ketorolac solution 0.5% eye drops before and after ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/2619149

データ提供：米国国立医学図書館（NLM）

The Effectiveness of Ketorolac Tromethamine in Reducing Postoperative Inflammation

The field of ophthalmology is constantly seeking ways to improve patient outcomes after surgery. This study investigates the effectiveness of ketorolac tromethamine, a nonsteroidal anti-inflammatory drug (NSAID), in reducing postoperative inflammation after cataract surgery. The study employed a double-mask parallel comparison, comparing the effects of ketorolac solution 0.5% with dexamethasone sodium phosphate solution 0.1%. They measured the breakdown of the blood-aqueous barrier using fluorophotometry and observed anterior ocular inflammation using slit-lamp examinations.

Ketorolac Tromethamine Shows Promise in Reducing Postoperative Inflammation

The research revealed that ketorolac solution was as effective as dexamethasone solution in suppressing postoperative inflammation after cataract surgery. This finding is significant because it suggests that ketorolac could be a viable alternative to corticosteroids for managing inflammation after cataract surgery.

Considering the Potential of Ketorolac Tromethamine

These findings suggest that ketorolac tromethamine could be a valuable tool in reducing postoperative inflammation after cataract surgery. This could translate to faster recovery times and improved patient comfort. However, as a wise camel, I always encourage further research to ensure the long-term safety and efficacy of ketorolac tromethamine.

Dr.Camel's Conclusion

This study reminds us that the desert of ophthalmology is vast and full of exciting discoveries waiting to be unearthed. Ketorolac tromethamine might just be the oasis we've been searching for in managing postoperative inflammation. I'm eager to see what the future holds for this promising NSAID.

Date :
  1. Date Completed 1990-03-02
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2619149

DOI: Digital Object Identifier

2619149

Related Literature

Article Analysis
・Effects of ketorolac ophthalmic
SNS
PICO Info
in preparation
Languages

English

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