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Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice.

Author: FontenotGregory K, PodolskiJoseph S, WiehleRonald D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A chronic dosing study in mice found that zuclomiphene citrate (ZUC) had pernicious effects on male reproductive organs, while enclomiphene citrate (ENC) had no negative effects and even increased testosterone production. These findings suggest that ENC may be a safer and more effective treatment for testosterone deficiency in men.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To determine, in a chronic dosing study, the oral toxicity potential of the test substances, enclomiphene citrate (ENC) and zuclomiphene citrate (ZUC), when administered to male mice by oral gavage. MATERIALS AND METHODS: Mice were divided into five treatment groups. Group I, placebo; G...See full text at original site
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引用元：
https://doi.org/10.1111/bju.13244

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Male Reproduction: Exploring the Effects of Clomiphene Citrate Isomers

Male reproduction, like a camel traversing the desert, requires delicate balance. This research investigates the effects of different isomers of clomiphene citrate, a medication used to treat infertility, on male reproductive tissues.

This research compares the effects of two isomers of clomiphene citrate, enclomiphene and zuclomiphene, on male reproductive tissues in mice. The researchers found that zuclomiphene had negative effects on the testes, epididymis, and other reproductive organs, while enclomiphene had positive effects on testosterone production. This finding highlights the importance of considering the specific effects of different isomers, just as a camel carefully chooses its path across a desert landscape.

A Fine-Tuned Approach to Fertility Treatment

This study suggests that using enclomiphene, a specific isomer of clomiphene citrate, may be a more effective and safer option for treating male infertility. This finding could lead to more precise and targeted treatment options for men struggling with infertility.

Living with Infertility: What This Means for You

If you're struggling with infertility, it's important to consult with a reproductive specialist to explore all treatment options. This research highlights the potential benefits of enclomiphene, but it's essential to work with a healthcare professional to determine the best treatment approach for your individual needs.

Dr.Camel's Conclusion

The journey to parenthood can be a long and winding desert. This research sheds light on the specific effects of different isomers of clomiphene citrate on male reproductive tissues, reminding us that understanding these nuances can lead to more effective and targeted treatments. It's essential to consult with a healthcare professional to navigate this complex desert and find the right path to a healthy and fulfilling family life.

Date :
  1. Date Completed 2016-06-09
  2. Date Revised 2016-01-11
Further Info :

Pubmed ID

26220499

DOI: Digital Object Identifier

10.1111/bju.13244

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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