Paper Details

  1. Home
  2. Paper Details

Intramuscular olanzapine for agitated patients: A systematic review and meta-analysis of randomized controlled trials.

Author: IwataNakao, KishiTaro, MatsunagaShinji

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This updated systematic review and meta-analysis compared intramuscular olanzapine (OLA-IM) with placebo and other antipsychotics for the treatment of agitation in patients. OLA-IM was superior to placebo and showed comparable efficacy to haloperidol (HAL-IM) with fewer side effects.
Paper Details　
Original Abstract of the Article :
We performed an updated systematic review and meta-analysis of randomized controlled trials (RCTs) of intramuscular (IM)-olanzapine (OLA-IM) versus controls in agitated patients. The risk ratio, number-needed-to-treat/harm, and standardized mean difference based on a random effects model were calcul...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.jpsychires.2015.07.005

データ提供：米国国立医学図書館（NLM）

Intramuscular Olanzapine: A Oasis in the Desert of Agitation

Agitation is a common and distressing symptom often encountered in patients with various mental health conditions. This research compares intramuscular (IM) olanzapine (OLA-IM) to other treatments for agitated patients, examining its efficacy and safety profile. The authors sought to evaluate the effectiveness of OLA-IM in reducing agitation, providing valuable insights for healthcare providers seeking to manage this challenging symptom.

The authors recognized the need for effective and safe treatments for agitation, seeking to provide relief for patients experiencing this distressing symptom. Their research, like a camel navigating a desert, seeks to find a solution that provides relief and comfort for those in need.

A Comparative Analysis: Navigating the Path to Relief

The authors conducted a systematic review and meta-analysis of randomized controlled trials (RCTs), comparing OLA-IM to placebo, haloperidol (HAL-IM), ziprasidone (ZIP-IM), and other medications. Their findings revealed that OLA-IM was superior to placebo in reducing agitation, offering a promising treatment option for patients struggling with this symptom.

Finding the Right Path: Balancing Efficacy and Safety

The authors found that OLA-IM was associated with fewer side effects compared to HAL-IM, highlighting its potential as a safer alternative for patients seeking to manage agitation. This research provides valuable insights for healthcare providers, guiding them in selecting the most appropriate treatment based on the individual needs and circumstances of each patient.

Dr. Camel's Conclusion

This research provides valuable insights into the efficacy and safety profile of intramuscular olanzapine for the treatment of agitated patients. The study findings suggest that OLA-IM is a promising option for reducing agitation, offering a potential oasis of relief for those experiencing this distressing symptom.

Date :
  1. Date Completed 2016-06-17
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

26228420

DOI: Digital Object Identifier

10.1016/j.jpsychires.2015.07.005

Related Literature

Article Analysis
・Side Effects of ziprasidone injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.