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Comparative efficacy of non-steroidal anti-inflammatory drugs in ankylosing spondylitis: a Bayesian network meta-analysis of clinical trials.

Author: DasguptaAbhijit, WangRunsheng, WardMichael M

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

A systematic review of 26 trials (66 treatment arms) of 20 NSAIDs in patients with active ankylosing spondylitis (AS) found that etoricoxib was more effective in reducing pain than some other NSAIDs. However, there was otherwise insufficient evidence to conclude that any particular NSAID was more effective in the treatment of AS.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To compare the efficacy of 20 non-steroidal anti-inflammatory drugs (NSAIDs) in the short-term treatment of ankylosing spondylitis (AS). METHODS: We performed a systematic literature review of randomised controlled trials of NSAIDs in patients with active AS. We included trials that repo...See full text at original site
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引用元：
https://doi.org/10.1136/annrheumdis-2015-207677

データ提供：米国国立医学図書館（NLM）

Comparing NSAIDs for Ankylosing Spondylitis: A Bayesian Network Meta-analysis

The field of [ankylosing spondylitis (AS) treatment] is continuously exploring effective pain management strategies for patients with this chronic inflammatory disease. This study conducted a [Bayesian network meta-analysis] to compare the efficacy of [20 non-steroidal anti-inflammatory drugs (NSAIDs)] in the short-term treatment of AS. The researchers aimed to identify the most effective NSAIDs for reducing pain and improving function in patients with active AS.

NSAIDs for Ankylosing Spondylitis: Etoricoxib Shows Promise

The meta-analysis included data from [26 trials] and found that all 20 NSAIDs reduced pain more than placebo. Etoricoxib demonstrated superior pain reduction compared to celecoxib, ketoprofen, and tenoxicam. However, no significant differences were found among the NSAIDs in terms of reducing morning stiffness or the likelihood of adverse events. The authors acknowledge the limitations of their study due to the small size of some trials and call for further research with larger sample sizes to confirm these findings.

Ankylosing Spondylitis and Pain Management: Seeking Relief

If you are diagnosed with AS, discuss pain management options with your doctor. They can recommend the most appropriate NSAID based on your individual needs and risk factors. It’s important to remember that NSAIDs can have side effects, so it’s crucial to use them as directed and discuss any concerns with your doctor. Remember, managing pain is an essential part of living well with AS.

Dr. Camel’s Conclusion

This meta-analysis sheds light on the comparative efficacy of NSAIDs for managing pain in patients with AS. While etoricoxib showed promising results in reducing pain, further research is needed to confirm these findings and provide a more comprehensive understanding of the effectiveness of various NSAIDs for treating AS. Remember, managing pain is a crucial aspect of living well with AS, and working closely with your doctor to find the most effective pain management approach is essential.

Date :
  1. Date Completed 2017-05-23
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26248636

DOI: Digital Object Identifier

10.1136/annrheumdis-2015-207677

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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