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The Thyroid Hormone Analog DITPA Ameliorates Metabolic Parameters of Male Mice With Mct8 Deficiency.

Author: DumitrescuAlexandra M, FerraraAlfonso Massimiliano, LiaoXiao-Hui, RefetoffSamuel, WeissRoy E, YeHonggang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of diiodothyropropionic acid (DITPA) on thyroid tests in serum and metabolism in Mct8-deficient (Mct8KO) mice, finding that DITPA ameliorated hypermetabolism but had no effect on brain hypothyroidism.
Paper Details　
Original Abstract of the Article :
Mutations in the gene encoding the thyroid hormone (TH) transporter, monocarboxylate transporter 8 (MCT8), cause mental retardation in humans associated with a specific thyroid hormone phenotype manifesting high serum T3 and low T4 and rT3 levels. Moreover, these patients have failure to thrive, and...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606752/

データ提供：米国国立医学図書館（NLM）

DITPA: A Potential Treatment for Mct8 Deficiency

The complexities of thyroid hormone metabolism are akin to navigating a vast desert of biochemical pathways. This research focuses on Mct8 deficiency, a genetic disorder affecting thyroid hormone transport and resulting in severe developmental delays. The authors investigate the potential of DITPA, a thyroid hormone analog, to ameliorate metabolic abnormalities associated with Mct8 deficiency, offering a potential treatment strategy for this challenging condition.

DITPA: A Beacon of Hope for Mct8 Deficiency

This research, much like a well-stocked oasis in the desert, offers a potential solution for the metabolic challenges faced by individuals with Mct8 deficiency. The findings suggest that DITPA can effectively normalize serum T3 levels and improve metabolic parameters, providing a promising avenue for treatment. Further research is needed to fully understand the long-term effects of DITPA and to establish optimal dosage and treatment regimens.

Managing Mct8 Deficiency

This research, like a map guiding us through the complex terrain of thyroid disorders, provides valuable insights into the potential of DITPA for managing Mct8 deficiency. While further research is needed, this study offers hope for a more effective treatment strategy for this debilitating condition. By understanding the mechanisms of DITPA action, we can pave the way for personalized treatment plans that address the unique needs of individuals with Mct8 deficiency.

Dr.Camel's Conclusion

This research, much like a caravan carrying precious cargo, delivers promising insights into the treatment of Mct8 deficiency. DITPA, a novel thyroid hormone analog, holds the potential to improve the lives of individuals affected by this challenging condition.
Date :
  1. Date Completed 2016-04-12
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

26322373

DOI: Digital Object Identifier

PMC4606752

SNS
PICO Info
in preparation
Languages

English

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