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Base-Modified Nucleosides as Chemotherapeutic Agents: Past and Future.
Author: BorlandKayla M, BurkeMatthew P, LitoshVladislav A
Original Abstract of the Article :
Nucleoside and nucleobase antimetabolites have substantially impacted treatment of cancer and infections. Their close resemblance to natural analogs gives them the power to interfere with a variety of intracellular targets, which on one hand gives them high potency, but on the other hand incurs seve...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.2174/1568026615666150915111933
データ提供:米国国立医学図書館(NLM)
Base-Modified Nucleosides: A New Frontier in Cancer Therapy
Nucleoside and nucleobase antimetabolites have been instrumental in treating cancer and infections. However, their close resemblance to natural counterparts often leads to severe side effects. This research explores the potential of novel base-modified nucleosides to develop more effective and less toxic cancer therapies. The study delves into the mechanisms of action of existing antimetabolites and explores promising strategies for developing new nucleoside analogs with improved therapeutic profiles.Beyond Conventional Chemotherapy: A New Era of Precision
The study emphasizes the importance of developing novel nucleoside analogs with improved therapeutic windows. The authors outline strategies for modifying nucleobases to create compounds that selectively target cancer cells while minimizing off-target toxicity. It's like finding a new path through the desert, a more precise and targeted approach to cancer treatment.Cancer Treatment: A Quest for Precision and Safety
This study underscores the need for innovative approaches to cancer therapy, focusing on developing drugs with enhanced efficacy and reduced side effects. The exploration of base-modified nucleosides represents a promising avenue for achieving this goal. It's a journey towards a more refined and personalized approach to cancer treatment, ensuring greater precision and safety for patients.Dr.Camel's Conclusion
This study delves into the exciting world of base-modified nucleosides, exploring their potential as novel cancer therapies. The research highlights the importance of developing targeted and less toxic treatments, paving the way for a more patient-centered and effective approach to cancer care. It's a quest for new oases in the desert of cancer treatment, offering hope for a brighter future for patients.Date :
- Date Completed 2016-11-02
- Date Revised 2019-09-07
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