Functionalized gold nanoparticles improve afatinib delivery into cancer cells.

Author: AlmeidaGabriela M, CoelhoManuel A N, CoelhoSílvia Castro, PereiraMaria Carmo, Santos-SilvaFilipe

Paper Details 
Original Abstract of the Article :
OBJECTIVES: A drug delivery system based on colloidal pegylated gold nanoparticles (PEGAuNPs) conjugated with the tyrosine kinase inhibitor afatinib was designed and tested for enhancing the drug activity against pancreatic and NSCLC cells. METHODS: PEGAuNPs were synthesized and characterized physi...See full text at original site
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引用元:
https://doi.org/10.1517/17425247.2015.1083973

データ提供:米国国立医学図書館(NLM)

Gold Nanoparticles: A Novel Approach to Cancer Treatment

Cancer research is a vast and challenging landscape, like a seemingly endless desert. Scientists are continuously exploring new strategies to combat this complex disease. This study investigates the potential of functionalized gold nanoparticles (PEGAuNPs) as a novel drug delivery system for afatinib, a tyrosine kinase inhibitor used in the treatment of certain cancers. The researchers used a combination of chemical synthesis, imaging techniques, and cell-based assays to evaluate the effectiveness of this approach. Their findings suggest that PEGAuNPs significantly enhance the activity of afatinib, leading to a more potent antitumor effect. This discovery is like finding a hidden oasis in the cancer research desert, offering a promising new avenue for treating this deadly disease.

A More Effective Oasis in the Cancer Desert

The study found that PEGAuNPs-afatinib conjugates were significantly more potent than afatinib alone, achieving a 5 to 20 times greater potency in inhibiting the growth of pancreatic and NSCLC cancer cells. This groundbreaking discovery has the potential to revolutionize cancer therapy, offering a more targeted and effective approach.

Hope in the Desert of Cancer Treatment

This research offers a glimmer of hope in the vast and challenging landscape of cancer treatment. The potential of PEGAuNPs-afatinib conjugates could lead to more effective therapies, potentially reducing the side effects associated with traditional treatments. This approach could ultimately improve the lives of cancer patients, offering a more promising path towards recovery.

Dr. Camel's Conclusion

This study demonstrates the potential of functionalized gold nanoparticles as a novel drug delivery system for afatinib, offering a promising new approach to cancer therapy. The enhanced potency and reduced side effects of this strategy could transform the treatment landscape, providing a more effective oasis in the desert of cancer research.

Date :
  1. Date Completed 2016-08-15
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26371512

DOI: Digital Object Identifier

10.1517/17425247.2015.1083973

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PICO Info
in preparation
Languages

English

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