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Directly Observable Behavioral Effects of Lorcaserin in Rats.

Author: FranceCharles P, RiceKenner C, SerafineKatherine M

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.

Overview

Lorcaserin is a medication approved by the FDA for the treatment of obesity. It is thought to work by activating serotonin (5-HT)2C receptors. This study examined the behavioral effects of lorcaserin in rats and found that it activated not only 5-HT2C receptors, but also 5-HT2A and possibly 5-HT1A receptors at higher doses.
Paper Details　
Original Abstract of the Article :
(1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (lorcaserin) is approved by the United States Food and Drug Administration for treating obesity, and its therapeutic effects are thought to result from agonist activity at serotonin (5-HT)2C receptors. Lorcaserin has affinity for other 5-HT ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658489/

データ提供：米国国立医学図書館（NLM）

Lorcaserin: A Multifaceted Serotonin Receptor Agonist

The quest for effective treatments for obesity is ongoing. Lorcaserin, a drug approved by the FDA for weight management, is believed to work by activating serotonin (5-HT)2C receptors. But the story doesn't end there! This study explores the behavioral effects of lorcaserin and investigates its activity at different serotonin receptor subtypes.

Lorcaserin's Diverse Effects on Serotonin Receptors

The study found that lorcaserin, in addition to its activity at 5-HT2C receptors, also shows agonist activity at 5-HT2A and potentially 5-HT1A receptors. This multifaceted action suggests that lorcaserin's therapeutic effects may be mediated by a complex interplay of these different serotonin receptor subtypes. This discovery opens up new avenues for understanding the mechanisms behind lorcaserin's effectiveness.

A Deeper Understanding of Lorcaserin's Actions

This research provides valuable insights into the multifaceted actions of lorcaserin. By studying the effects of lorcaserin at different serotonin receptor subtypes, we gain a deeper understanding of its mechanisms of action. This knowledge can help refine its use in treating obesity and potentially lead to the development of even more effective weight management strategies.

Dr.Camel's Conclusion

The desert landscape of obesity is a complex and multifaceted challenge. This study provides a new perspective on lorcaserin's effects. By understanding its diverse actions, we can potentially create more effective and targeted approaches to combat obesity. Remember, the journey to a healthier life is a continuous process, and we must continue to explore new paths and insights.

Date :
  1. Date Completed 2016-02-09
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

26384326

DOI: Digital Object Identifier

PMC4658489

Related Literature

Article Analysis
・Effects of lorcaserin
SNS
PICO Info
in preparation
Languages

English

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