Enhanced eryptosis following auranofin exposure.

Author: AbedMajed, AlzoubiKousi, EglerJasmin, LangFlorian

Paper Details 
Original Abstract of the Article :
The antiinflammatory, antimicrobial and anticancer drug auranofin has previously been shown to trigger apoptosis, the suicidal death of nucleated cells. Side effects of the drug include anaemia. At least in theory the anaemia could result from stimulation of suicidal death of erythrocytes or eryptos...See full text at original site
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引用元:
https://doi.org/10.1159/000430228

データ提供:米国国立医学図書館(NLM)

Auranofin: A Double-Edged Sword in Cancer Treatment

Auranofin, a drug known for its anti-inflammatory, antimicrobial, and anticancer properties, has been shown to trigger apoptosis, a form of programmed cell death in nucleated cells. However, it can also induce eryptosis, a type of suicidal death in erythrocytes, potentially leading to anemia. This research investigated the effects of auranofin on eryptosis, examining its potential role in the drug's side effects.

The Hidden Costs of Cancer Treatment: A Balancing Act

The study revealed that auranofin exposure significantly enhanced eryptosis. This finding suggests a potential mechanism for the anemia associated with auranofin treatment. It emphasizes the need for careful consideration of the potential risks and benefits of this drug, particularly in patients with pre-existing anemia.

Navigating the Complexities of Cancer Treatment: A Delicate Dance

Understanding the intricate relationship between auranofin and eryptosis is essential for optimizing its use in cancer treatment. This research highlights the delicate balance between therapeutic efficacy and potential side effects, underscoring the importance of personalized medicine approaches in cancer care. Balancing the benefits and risks of auranofin treatment requires a careful assessment of each patient's individual needs and risk factors.

Dr.Camel's Conclusion

The quest for effective cancer treatments is a challenging journey, often fraught with unexpected twists and turns. Auranofin, a promising weapon against cancer, has a hidden side effect: eryptosis. This research, like a compass guiding us through the complexities of cancer treatment, sheds light on the potential risks associated with auranofin. Balancing its benefits and risks requires a careful and thoughtful approach, ensuring that the treatment's advantages outweigh its potential drawbacks.

Date :
  1. Date Completed 2016-08-08
  2. Date Revised 2019-02-12
Further Info :

Pubmed ID

26397807

DOI: Digital Object Identifier

10.1159/000430228

Related Literature

SNS
PICO Info
in preparation
Languages

English

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