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[Role of Human Orphan Esterases in Drug-induced Toxicity].

Author: FukamiTatsuki

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
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Overview

This study explores the roles of orphan esterases, particularly AADAC and ABHD10, in drug metabolism and toxicity. AADAC is involved in the hydrolysis of several drugs, potentially contributing to hepatotoxicity and methemoglobinemia. ABHD10 functions as a detoxification enzyme, deglucuronidating acyl-glucuronides, which are often associated with toxicity. This research highlights the growing understanding of orphan esterases in drug therapy and their significance in pharmacologic and toxicological contexts.
Paper Details　
Original Abstract of the Article :
Esterases hydrolyze compounds containing ester, amide, and thioester bonds, causing prodrug activation or detoxification. Among esterases, carboxylesterases have been studied in depth due to their ability to hydrolyze a variety of drugs. However, there are several drugs for which the involved estera...See full text at original site
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引用元：
https://doi.org/10.1248/yakushi.15-00186

データ提供：米国国立医学図書館（NLM）

Orphan Esterases: Uncovering the Hidden Roles in Drug-Induced Toxicity

Drug development is like a vast desert, with many hidden dangers lurking in the sand. Researchers are constantly working to understand the complex interactions between drugs and the human body. This research focuses on orphan esterases, a group of enzymes that play a crucial role in drug metabolism, and their potential involvement in drug-induced toxicity. It's like uncovering a hidden network of tunnels that could lead to understanding the mechanisms of drug toxicity.

Orphan Esterases: Key Players in Drug Metabolism and Toxicity

The study highlights the significance of orphan esterases in drug metabolism and their potential contribution to drug-induced toxicity. It's like discovering a new tribe in the desert, with its own unique customs and traditions. The researchers found that several drugs, including flutamide, phenacetin, and rifamycins, are hydrolyzed by orphan esterases, which can lead to both drug activation and detoxification. This research is a reminder that we need to consider the role of these enzymes when developing new drugs and understanding their potential side effects.

Drug Safety: Navigating the Desert of Metabolism

This research highlights the importance of understanding the intricate processes of drug metabolism and the role of orphan esterases in this complex interplay. It’s like carefully navigating a desert landscape, understanding the terrain and potential dangers. This research underscores the importance of further research on orphan esterases, which could lead to safer drug development and better management of drug-induced toxicity.

Dr.Camel's Conclusion

This research is a valuable contribution to the field of drug development, reminding us that there is still much to learn about the complex interactions between drugs and the human body. It’s like uncovering a new layer of the desert, revealing a hidden world of biological processes that can influence drug efficacy and safety. This research underscores the importance of ongoing research in this field, which could lead to significant advancements in drug development and patient safety.

Date :
  1. Date Completed 2016-06-13
  2. Date Revised 2015-11-02
Further Info :

Pubmed ID

26521872

DOI: Digital Object Identifier

10.1248/yakushi.15-00186

SNS
PICO Info
in preparation
Languages

Japanese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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