Brodalumab, a human anti-interleukin-17-receptor antibody in the treatment of Japanese patients with moderate-to-severe plaque psoriasis: Efficacy and safety results from a phase II randomized controlled study.

Author: , NakagawaHidemi, NiiroHiroaki, OotakiKenji

Paper Details 
Original Abstract of the Article :
Brodalumab (KHK4827 or AMG 827) is a human monoclonal antibody that binds to the human interleukin (IL)-17 receptor A and blocks the biological activities of IL-17A, IL-17F, IL-17A/F, and IL-17E also known as IL-25. A 12-week phase 2 trial in the USA, Europe, and other countries showed the good effi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.jdermsci.2015.10.009

データ提供:米国国立医学図書館(NLM)

Brodalumab: A New Hope for Moderate-to-Severe Plaque Psoriasis?

The search for effective treatments for [moderate-to-severe plaque psoriasis] continues. This phase II study explored the efficacy and safety of [brodalumab], a [human monoclonal antibody] that targets the [IL-17 receptor], in [Japanese patients]. The research builds on previous findings from [a 12-week phase 2 trial in the USA, Europe, and other countries] that demonstrated the [good efficacy of brodalumab] in treating [moderate to severe plaque psoriasis]. This study, conducted in [Japan], provides further evidence regarding the potential of [brodalumab] as a treatment option for [plaque psoriasis].

Promising Results for Plaque Psoriasis

The results of this phase II trial show the promising efficacy of [brodalumab] in treating [moderate-to-severe plaque psoriasis] in [Japanese patients]. The study's findings, akin to a desert bloom after a rare rainfall, offer hope for those struggling with this chronic skin condition. This research adds to the growing body of evidence supporting the potential of [brodalumab] as a viable treatment option.

A New Path for Psoriasis Treatment

This study suggests that [brodalumab] could be a valuable tool in the treatment of [plaque psoriasis]. Just as a camel adapts to its harsh desert environment, this drug may offer patients with [plaque psoriasis] a new path towards managing their condition and improving their quality of life.

Dr. Camel's Conclusion

This research adds another promising chapter to the ongoing search for effective treatments for [plaque psoriasis]. Brodalumab emerges as a potential treatment option with a demonstrated efficacy in Japanese patients. Like a camel traversing the vast desert, this research sheds light on a new path toward managing this chronic skin condition.

Date :
  1. Date Completed 2016-10-07
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

26547109

DOI: Digital Object Identifier

10.1016/j.jdermsci.2015.10.009

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.