Paper Details

  1. Home
  2. Paper Details

Intrathecal methadone and morphine for postoperative analgesia: a comparison of the efficacy, duration, and side effects.

Author: BrodyM C, ChabalC, IretonR C, JacobsonL, WardR J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.

Overview

Intrathecal morphine (0.5 and 1 mg) provides superior postoperative analgesia to 1 mg methadone. While morphine provided effective and prolonged analgesia, methadone was unable to ensure the same degree of analgesia. The median pain scores were consistently higher following methadone than morphine. The time to onset of severe discomfort requiring supplemental morphine was also significantly longer after morphine than methadone. Respiratory depression was common following morphine 1 mg, but not associated with methadone and morphine 0.5 mg. Facial pruritus was unique to intrathecal morphine.
Paper Details　
Original Abstract of the Article :
A double-blind study of patients selected at random compared the analgesic and adverse effects of intrathecal methadone (1 mg) with those of intrathecal morphine (0.5 and 1 mg). The study was conducted on 30 patients who underwent major orthopedic or urologic surgery. The intrathecal opioid was admi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1097/00000542-198905000-00005

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 1989-06-12
  2. Date Revised 2019-06-28
Further Info :

Pubmed ID

2655501

DOI: Digital Object Identifier

10.1097/00000542-198905000-00005

Related Literature

Article Analysis
・Side Effects of methadone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.