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Efficacy of felodipine in congestive heart failure.

Author: DunselmanP H, HamerJ P, KuntzeC E, LieK I, ScafA H, WesslingH, van BruggenA

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Felodipine, a vasodilating calcium antagonist, has a beneficial effect in patients with moderately severe heart failure. In an 8-week, double-blind, randomized, placebo-controlled study of 23 patients, felodipine significantly increased exercise duration without changes in oxygen consumption. Heart rate, arterial pressures, and rate pressure product decreased at similar submaximal exercise levels. Side effects were minor and fluid retention did not occur. Further research is needed to demonstrate its long-term efficacy and safety.
Paper Details　
Original Abstract of the Article :
The efficacy of felodipine, a vasodilating calcium antagonist, was analysed in 23 patients with congestive heart failure, New York Heart Association class III, during an 8-week, double-blind, randomized, placebo-controlled, parallel study. After felodipine, exercise duration increased significantly ...See full text at original site
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引用元：
https://doi.org/10.1093/oxfordjournals.eurheartj.a059493

データ提供：米国国立医学図書館（NLM）

Felodipine: A Hope for Hearts in Distress

This research focuses on the efficacy of felodipine, a vasodilating calcium antagonist, in treating congestive heart failure (CHF). The study involved 23 patients with CHF, a condition where the heart struggles to pump blood efficiently. These patients were randomly assigned to receive either felodipine or a placebo.

Felodipine: A Gentle but Powerful Ally for the Heart

The results indicated that felodipine improved exercise tolerance in CHF patients without increasing their oxygen consumption. It also reduced heart rate, arterial pressure, and heart workload. The study further showed that felodipine caused vasodilation, which is the widening of blood vessels, without causing reflex tachycardia, an increase in heart rate. These findings suggest that felodipine may offer a safe and effective treatment option for patients with CHF. Imagine a thirsty traveler in the desert: felodipine acts like a refreshing oasis, relieving the strain and promoting well-being.

Living with CHF: Hope and Caution

While this study provides encouraging evidence for the benefits of felodipine in CHF, it also emphasizes the need for further research to establish its long-term efficacy and safety. As a researcher, I always encourage careful consideration and a nuanced approach to any new treatment. Just as a camel needs to be carefully guided across the desert, we must proceed with caution and thorough research to ensure the safety and effectiveness of new therapies.

Dr. Camel's Conclusion

This study offers a glimmer of hope for patients with CHF. The findings suggest that felodipine may be a valuable therapeutic option for improving exercise capacity and reducing heart strain. However, more research is needed to fully understand its long-term impact. As a seasoned researcher, I have learned that patience is key, and I look forward to seeing the results of future studies that will further illuminate the potential of this promising drug.
Date :
  1. Date Completed 1989-06-28
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

2656266

DOI: Digital Object Identifier

10.1093/oxfordjournals.eurheartj.a059493

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SNS
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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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