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Digitoxin and its synthetic analog MonoD have potent antiproliferative effects on lung cancer cells and potentiate the effects of hydroxyurea and paclitaxel.
Author: AzadNeelam, IyerAnand Krishnan V, KaushikVivek, KulkarniYogesh, O'DohertyGeorge A, VenkatadriRajkumar, WrightClayton, YakisichJuan Sebastian
Original Abstract of the Article :
Despite significant advances in the understanding of lung cancer biology, the prognosis of cancer patients remains poor. Part of the failure of anticancer therapy is due to intratumoral heterogeneity in these patients that limits the efficacy of single agents. Therefore, there is an urgent need for ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689486/
データ提供:米国国立医学図書館(NLM)
Digitoxin and MonoD: A New Weapon Against Lung Cancer
Lung cancer, like a relentless desert storm, continues to pose a significant threat to human health. This study, like a determined caravan searching for a new route to victory, investigates the potential of digitoxin and MonoD, cardiac glycosides, as anti-cancer agents against lung cancer cells. The researchers, like skilled warriors, sought to find new ways to combat this deadly disease.A Promising Alliance Against Lung Cancer
The study's findings, like a well-organized caravan, reveal that both digitoxin and MonoD exhibited potent anti-proliferative effects against lung cancer cells, even under conditions of limited nutrients. Additionally, these medications showed a synergistic effect when combined with other anti-cancer drugs like hydroxyurea and paclitaxel.Battling the Desert Storm: Hope for Lung Cancer Patients
Lung cancer, like a scorching desert sun, can be difficult to defeat. This study offers a glimmer of hope, highlighting the potential of digitoxin and MonoD as new weapons in the fight against this deadly disease. While further research is necessary, these findings provide a promising avenue for developing new and more effective treatments for lung cancer.Dr. Camel's Conclusion
This study, like a camel caravan carrying precious supplies, brings hope to the battle against lung cancer. The researchers, like skilled healers, have discovered new potential weapons in digitoxin and MonoD, offering a ray of hope for those battling this disease.Date :
- Date Completed 2016-09-30
- Date Revised 2018-11-13
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