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Mechanism of Action, Efficacy, and Adverse Events of Calcium Antagonists in Hypertrophic Scars and Keloids: A Systematic Review.

Author: Piatkowski de GrzymalaAndrzej, VerhielSvenna, van der HulstRene

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Calcium antagonists have been found to be effective in reducing extracellular matrix production, inducing procollagenase synthesis, and inhibiting interleukin-6, vascular endothelial growth factor, and proliferation of fibroblasts in vitro. Clinical studies have shown good efficacy with no major side effects. However, further large-scale, high-quality studies are needed to optimally evaluate the efficacy of calcium antagonists in treating hypertrophic scars and keloids.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Pathological scars often cause major cosmetic and functional consequences, which make effective treatment important. Intralesional therapies are widely used, with corticosteroid injection considered to be first choice. An emerging and promising treatment option is the calcium antagonist ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/26606434

データ提供：米国国立医学図書館（NLM）

Calcium Antagonists: A Potential Oasis in the Desert of Scarring

Pathological scars, often leaving lasting marks on the body, can be a source of both cosmetic and functional concerns. This research delves into the potential of calcium antagonists, a class of drugs commonly used for cardiovascular conditions, to address this challenge. The researchers conducted a systematic review of existing literature to assess the efficacy and safety of calcium antagonists in the treatment of hypertrophic scars and keloids.

Exploring the Healing Potential of Calcium Antagonists

The research reveals intriguing insights into the mechanism of action of calcium antagonists. The studies suggest that calcium antagonists can potentially reduce the production of extra cellular matrix, a key component of scar tissue, and promote the breakdown of collagen. This discovery is like finding a hidden oasis in the desert of scarring, offering a potential path toward restoring the skin's normal appearance and function. The studies also suggest that calcium antagonists may be well-tolerated, with minimal side effects.

A New Approach to Scar Management

The research suggests that calcium antagonists might offer a promising approach to manage hypertrophic scars and keloids. This research, like a guidebook for clinicians, sheds light on the potential benefits and safety of these drugs, potentially leading to more effective treatment options for individuals struggling with scarring.

Dr.Camel's Conclusion

This research is like a caravan exploring the desert of scarring, searching for new ways to improve treatment outcomes. The studies suggest that calcium antagonists, like a refreshing oasis, might hold the key to managing hypertrophic scars and keloids. The research offers a promising path towards more effective treatment options for individuals seeking to minimize the impact of these challenging conditions.
Date :
  1. Date Completed 2016-03-14
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26606434

DOI: Digital Object Identifier

00042728-201512000-00001

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