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Anticholinergic effects on memory: benztropine versus amantadine.

Author: BrotmanA W, FalkW E, Galvin-NadeauM, GelenbergA J, LavoriP W, MarderS, MohsR C, SpringB, Van PuttenT, WojcikJ D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Benztropine, an anticholinergic agent, can impair cognition and other functions. In a double-blind crossover trial of 60 healthy volunteers, benztropine, but not amantadine, impaired free recall and perception of time. Subjects' perception of their own memory impairment was also significantly greater with benztropine. Benztropine decreased salivary flow to a greater degree than amantadine, and side effects were more common with benztropine.
Paper Details　
Original Abstract of the Article :
To evaluate anticholinergic effects on cognition and other functions, we studied 60 healthy volunteers in a double-blind crossover trial of two antiparkinsonian agents, benztropine and amantadine. Benztropine 4 mg/day, but not amantadine 200 mg/day, impaired free recall and perception of time, and s...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2661606

データ提供：米国国立医学図書館（NLM）

Anticholinergic Effects on Memory: A Comparative Study

This study explores the fascinating world of [pharmacology] and [cognition]. The research examines the [anticholinergic effects] of two [antiparkinsonian agents], [benztropine] and [amantadine] on [memory] and [time perception] in [healthy volunteers]. The study found that [benztropine] significantly impaired [free recall] and [time perception], while [amantadine] did not. This research suggests that [benztropine] may have a more pronounced negative impact on [memory] than [amantadine], highlighting the need for careful consideration of these potential side effects when prescribing anticholinergic medications.

The Impact of Anticholinergics on Memory: A Cautious Approach

This research provides valuable insights into the potential effects of [anticholinergic agents] on [memory]. The study found that [benztropine] had a greater negative impact on [free recall] and [time perception] compared to [amantadine]. This suggests that [benztropine] may be more likely to cause [memory impairments] in patients. It's important to be aware of these potential side effects and make informed decisions about the use of [anticholinergic agents] in clinical practice.

Prescribing Anticholinergics: Navigating a Complex Landscape

This study underscores the importance of carefully considering the potential [anticholinergic effects] of medications. The research highlights the significant impact that [benztropine] can have on [memory] and [time perception], while [amantadine] seems to have less of an effect. It's like navigating a desert landscape where certain paths can lead to unexpected challenges. By being mindful of the potential side effects of medications, we can make more informed decisions and ensure the best possible outcomes for patients.

Dr.Camel's Conclusion

Just like a camel navigating the vast and often treacherous desert, we must be mindful of the potential consequences of our actions. This research highlights the importance of considering the potential side effects of medications, particularly [anticholinergics], on our cognitive abilities. It's like carefully choosing a path through the desert, ensuring that we avoid any potential pitfalls that could hinder our progress.
Date :
  1. Date Completed 1989-08-01
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

2661606

DOI: Digital Object Identifier

2661606

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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