Paper Details

  1. Home
  2. Paper Details

Inhibition Profiling of Retroviral Protease Inhibitors Using an HIV-2 Modular System.

Author: MahdiMohamed, MótyánJános András, SzojkaZsófia, TőzsérJózsef

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Darunavir, saquinavir, indinavir, and lopinavir are effective HIV-2 protease inhibitors, while tipranavir, nelfinavir, and amprenavir have decreased efficacy. The I54M, L90M double mutation in the HIV-2 protease significantly reduced susceptibility to most of the inhibitors except tipranavir. This modular system is a novel approach for HIV-2 protease characterization and susceptibility testing.
Paper Details　
Original Abstract of the Article :
Retroviral protease inhibitors (PIs) are fundamental pillars in the treatment of HIV infection and acquired immunodeficiency syndrome (AIDS). Currently used PIs are designed against HIV-1, and their effect on HIV-2 is understudied. Using a modular HIV-2 protease cassette system, inhibition profiling...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690855/

データ提供：米国国立医学図書館（NLM）

Inhibition Profiling of Retroviral Protease Inhibitors Using an HIV-2 Modular System: A Journey Through the Desert of HIV Treatment

Retroviral protease inhibitors (PIs) are essential components of HIV treatment, targeting the viral protease enzyme to prevent viral replication. This research explores the effectiveness of HIV-1 PIs against HIV-2, investigating their inhibitory activity against a modular HIV-2 protease system. The authors conducted a series of inhibition profiling assays, examining the efficacy of various PIs in both enzymatic and cell culture settings. This study sheds light on the potential for repurposing HIV-1 PIs for HIV-2 treatment, offering a new avenue for combating this global health challenge.

A New Oasis in the Desert: Exploring the Potential of HIV-1 PIs for HIV-2 Treatment

This research delves into the potential for repurposing HIV-1 protease inhibitors for HIV-2 treatment, exploring their efficacy against a modular HIV-2 protease system. The study reveals that certain HIV-1 PIs exhibit significant inhibitory activity against HIV-2, offering a promising path towards new treatment options. This discovery is a beacon of hope in the desert of HIV treatment, suggesting a potential for expanded therapeutic strategies.

Navigating the Shifting Sands: Understanding the Complexities of HIV-2 Treatment

Navigating the shifting sands of HIV-2 treatment requires a comprehensive understanding of the virus and its response to various therapies. This research sheds light on the potential for repurposing HIV-1 protease inhibitors, providing valuable insights into the complex interplay between these drugs and HIV-2. By exploring the nuances of HIV-2 inhibition, researchers can pave the way for more effective and individualized treatment approaches, offering hope for those living with this challenging disease.

Dr. Camel's Conclusion

This research provides a comprehensive assessment of the inhibitory activity of HIV-1 protease inhibitors against HIV-2, offering valuable insights into the potential for repurposing these drugs for HIV-2 treatment. The study underscores the importance of continued research and development in exploring new therapeutic strategies for HIV-2 infection, offering hope for those living with this challenging disease.

Date :
  1. Date Completed 2016-09-29
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

26633459

DOI: Digital Object Identifier

PMC4690855

Related Literature

Article Analysis
・Effects of tipranavir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.