Stroke neuroprotection revisited: Intra-arterial verapamil is profoundly neuroprotective in experimental acute ischemic stroke.

Author: AronIshi, BixGregory J, FraserJustin F, ManiskasMichael E, RobertsJill M

Paper Details 
Original Abstract of the Article :
While clinical trials have now solidified the role of thrombectomy in emergent large vessel occlusive stroke, additional therapies are needed to optimize patient outcome. Using our previously described experimental ischemic stroke model for evaluating adjunctive intra-arterial drug therapy after ves...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821022/

データ提供:米国国立医学図書館(NLM)

Intra-Arterial Verapamil: A Potential Neuroprotective Adjunct to Thrombectomy

This research investigates the [potential neuroprotective effects of intra-arterial verapamil] in [experimental acute ischemic stroke]. The authors utilized a [well-established stroke model] to evaluate the impact of [verapamil administration] after [vessel recanalization]. Their findings demonstrate [significant neuroprotective effects of verapamil], including [reduced infarct volume, astrogliosis, and cellular apoptosis] alongside [increased neuronal survival and functional outcome]. This research highlights the [promising potential of intra-arterial verapamil] as a [therapeutic adjunct to thrombectomy] in treating ischemic stroke. A key takeaway from this study is the [safety and efficacy of intra-arterial verapamil administration], suggesting it could be a valuable addition to the treatment arsenal for ischemic stroke.

Intra-Arterial Verapamil: A Potential Neuroprotective Adjunct to Thrombectomy

This study provides a compelling case for further investigation into the use of intra-arterial verapamil as a neuroprotective therapy for ischemic stroke. The findings suggest that this approach could potentially improve patient outcomes and enhance the effectiveness of thrombectomy.

Intra-Arterial Verapamil: A Potential Neuroprotective Adjunct to Thrombectomy

This research underscores the importance of exploring innovative approaches to neuroprotection in ischemic stroke. It highlights the potential of intra-arterial verapamil as a safe and effective adjunct to thrombectomy, offering a promising avenue for improving treatment outcomes and minimizing neurological damage.

Dr.Camel's Conclusion

The desert, with its shifting sands and hidden currents, is a reminder of the unpredictable nature of stroke. This research, like a camel traversing the vast desert landscape, seeks to navigate the complex terrain of stroke recovery. It explores the potential of intra-arterial verapamil as a powerful tool for neuroprotection, offering a glimmer of hope for those seeking to restore function and reclaim their lives after a stroke.

Date :
  1. Date Completed 2016-08-10
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

26661189

DOI: Digital Object Identifier

PMC4821022

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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