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Double-Blind, Randomized Trial of Alternative Letrozole Dosing Regimens in Postmenopausal Women with Increased Breast Cancer Risk.

Author: BougheyJudy C, ChowH-H Sherry, FrankDenise, HsuChiu-Hsieh, LangJulie E, LeyMichele, LópezAna Maria, PerloffMarjorie, PruthiSandhya, TavernaJosephine A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

A double-blind, randomized trial was conducted to assess the efficacy and side effects of low and intermittent doses of letrozole, an aromatase inhibitor, for breast cancer prevention in high-risk postmenopausal women. The study found that low and intermittent doses of letrozole are not inferior to standard dose in estrogen suppression and resulted in a similar side-effect profile.
Paper Details　
Original Abstract of the Article :
Aromatase inhibitors (AI) profoundly suppress estrogen levels in postmenopausal women and are effective in breast cancer prevention among high-risk postmenopausal women. Unfortunately, AI treatment is associated with undesirable side effects that limit patient acceptance for primary prevention of br...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/26667449

データ提供：米国国立医学図書館（NLM）

Finding the Right Dose: A Balancing Act in Breast Cancer Prevention

Breast cancer, a formidable foe in the fight against [cancer], requires a multi-faceted approach to prevention and treatment. This study examines the effectiveness of various letrozole dosing regimens for breast cancer prevention in postmenopausal women. The research aims to find the right balance between efficacy and tolerability.

A Delicate Dance: Optimizing Letrozole Dosing for Breast Cancer Prevention

The study reveals that low and intermittent doses of letrozole can effectively suppress estrogen levels, achieving similar results to standard doses while potentially offering a more favorable side-effect profile. It's like finding the sweet spot in a delicate dance, striking a balance between efficacy and tolerability.

A Holistic Approach: Personalized Treatment for Breast Cancer Prevention

This research highlights the importance of individualizing treatment approaches, considering factors such as patient preferences and side-effect profiles. Finding the right dosing regimen for each patient can improve their overall experience with breast cancer prevention.

Dr.Camel's Conclusion

This study is a testament to the importance of finding the right balance in medical treatment. By carefully considering dosing regimens and individual patient needs, we can enhance the effectiveness of breast cancer prevention strategies and improve the quality of life for those at risk.

Date :
  1. Date Completed 2016-10-25
  2. Date Revised 2023-11-04
Further Info :

Pubmed ID

26667449

DOI: Digital Object Identifier

NIHMS745043

Related Literature

Article Analysis
・Effects of letrozole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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