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TPMT and ITPA genetic variants in Lithuanian inflammatory bowel disease patients: Prevalence and azathioprine-related side effects.
Author: DenapieneGoda, JonaitisLaimas, KiudelisGediminas, KupcinskasJuozas, KupcinskasLimas, SkiecevicieneJurgita, SteponaitieneRuta, SurvilaiteSanta, ValantinasJonas, VarkalaiteGreta
Original Abstract of the Article :
Inter-individual thiopurine metabolism variability can influence treatment outcomes in inflammatory bowel disease (IBD) patients. Genetic polymorphisms in thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) were linked with toxicity of azathioprine (AZA). The aim of t...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.advms.2015.09.008
データ提供:米国国立医学図書館(NLM)
Personalized Medicine: Tailoring Treatment for IBD
Inflammatory bowel disease (IBD), a chronic condition affecting the digestive system, can significantly impact a patient's quality of life. Finding the right treatment for IBD often requires a personalized approach, considering individual patient factors, including genetic predisposition.This research explores the role of genetic polymorphisms in thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) in Lithuanian IBD patients, analyzing their association with azathioprine (AZA)-related side effects. The study highlights the potential for using genetic information to optimize AZA treatment for IBD patients, minimizing the risk of adverse events. Think of it as a desert expedition where understanding the terrain, including potential hazards, is crucial for a successful journey.
Optimizing Treatment: The Power of Genetics
This research highlights the potential of personalized medicine in improving IBD treatment outcomes. It emphasizes the importance of considering genetic factors to optimize treatment regimens and minimize the risk of adverse events.Managing IBD: The Importance of Collaboration
This research underscores the importance of close collaboration between healthcare professionals and IBD patients. Working together to understand individual needs and tailoring treatment accordingly is essential for achieving optimal patient outcomes.Dr. Camel's Conclusion
The desert of IBD treatment is a complex and challenging landscape. This research offers a valuable oasis – personalized medicine, where genetic information can guide treatment decisions and improve patient outcomes. By embracing a collaborative approach and utilizing the power of genetics, we can help IBD patients navigate this challenging terrain more effectively.Date :
- Date Completed 2017-01-09
- Date Revised 2018-12-11
Further Info :
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