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Brain stem as a target site for the metabolic side effects of olanzapine.

Author: AnwarImran J, MiyataKayoko, ZsombokAndrea

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Olanzapine, an atypical antipsychotic, may cause metabolic side effects by hyperpolarizing neurons in the dorsal motor nucleus of the vagus nerve (DMV).
Paper Details　
Original Abstract of the Article :
Olanzapine, an atypical antipsychotic, is widely prescribed for the treatment of schizophrenia and bipolar disorder despite causing undesirable metabolic side effects. A variety of mechanisms and brain sites have been proposed as contributors to the side effects; however, the role of the dorsal moto...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808124/

データ提供：米国国立医学図書館（NLM）

Olanzapine's Metabolic Side Effects: A Focus on the Brain Stem

This study investigates the potential role of the brain stem in mediating the metabolic side effects of olanzapine, an atypical antipsychotic medication. The researchers focused on the dorsal motor nucleus of the vagus nerve (DMV), a critical area in the brain stem involved in regulating energy and glucose homeostasis. Using electrophysiological recordings in mice, the study found that olanzapine hyperpolarized DMV neurons, suggesting a decrease in vagal output to organs involved in metabolism. The researchers posit that this effect may contribute to the metabolic side effects observed in individuals taking olanzapine.

Olanzapine and the Brain Stem: A Complex Relationship

This study suggests that the brain stem, particularly the DMV, may play a significant role in mediating the metabolic side effects of olanzapine. The findings highlight the intricate connection between the brain and metabolic processes, providing valuable insights into the potential mechanisms underlying olanzapine's metabolic effects.

Metabolic Side Effects: A Camel's Perspective on Energy Balance

As a camel, I've learned to conserve energy in the desert, much like our bodies regulate metabolism. This study reminds us that the brain, specifically the brain stem, plays a vital role in maintaining energy balance. Understanding the impact of medications like olanzapine on this critical area can help us develop strategies to mitigate potential metabolic side effects.

Dr.Camel's Conclusion

This study sheds light on the potential role of the brain stem, specifically the DMV, in mediating the metabolic side effects of olanzapine. It underscores the intricate connection between the brain and metabolic processes, providing valuable insights into the potential mechanisms underlying olanzapine's metabolic effects.
Date :
  1. Date Completed 2016-11-14
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26719086

DOI: Digital Object Identifier

PMC4808124

Related Literature

Article Analysis
・Side Effects of olanzapine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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