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Mechanisms for the Specific Properties of γ-Hydroxybutyrate in Brain.

Author: KleinChristian, MaitreMichel, Mensah-NyaganAyikoe G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This abstract reviews the role of gamma-hydroxybutyrate (GHB) in the brain, discussing its therapeutic uses and potential for abuse.
Paper Details　
Original Abstract of the Article :
γ-Hydroxybutyrate (GHB) is both a natural brain compound with neuromodulatory properties at central GABAergic synapses (micromolar concentration range) and also a drug (Xyrem(R) ) clinically used for the treatment of various neurological symptoms (millimolar dose range). However, this drug has abuse...See full text at original site
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引用元：
https://doi.org/10.1002/med.21382

データ提供：米国国立医学図書館（NLM）

Unlocking the Secrets of γ-Hydroxybutyrate: A Desert Expedition into the Brain

The brain, a complex and fascinating desert landscape, holds many secrets. This study focuses on γ-Hydroxybutyrate (GHB), a naturally occurring brain compound that plays a role in brain activity. While GHB has therapeutic potential, its use as a drug carries risks of abuse and addiction. This research delves into the mechanisms of action of GHB, aiming to develop new drugs that retain its therapeutic benefits while minimizing side effects.

The Double-Edged Sword of γ-Hydroxybutyrate: A Desert Oasis with Hidden Dangers

This research uncovers the intricate mechanisms of GHB, a molecule with the potential to be both a blessing and a curse. The study highlights the need for a deeper understanding of GHB's actions in the brain. Finding a way to harness the therapeutic benefits of GHB while mitigating its abuse potential is a critical challenge. This research serves as a stepping stone towards developing safer and more effective GHB-like drugs.

Navigating the Desert of Drug Development

Understanding the complex interactions of drugs like GHB is essential for safe and effective medication development. Navigating the desert of drug development is a delicate dance, requiring a careful balance of benefits and risks. The authors' work provides crucial insights into the intricate workings of GHB, paving the way for the development of new medications that can benefit patients without the risk of addiction.

Dr.Camel's Conclusion

The brain is a vast and intricate desert, and understanding its secrets is a continuous journey. This research illuminates the potential of GHB as a therapeutic agent while acknowledging its inherent risks. By delving into the intricate mechanisms of action of this molecule, we can pave the way for the development of new drugs that offer both benefit and safety.

Date :
  1. Date Completed 2016-12-27
  2. Date Revised 2016-12-30
Further Info :

Pubmed ID

26739481

DOI: Digital Object Identifier

10.1002/med.21382

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Languages

English

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