Comparative Safety and Tolerability of Prostacyclins in Pulmonary Hypertension.

Author: AmarDavid, BouclyAthénaïs, ChaumaisMarie-Camille, HumbertMarc, JaïsXavier, MontaniDavid, O'ConnellCaroline, SavaleLaurent, SimonneauGérald, SitbonOlivier

Paper Details 
Original Abstract of the Article :
Prostacyclin (PGI2) is a prostaglandin derived from arachidonic acid in the endothelium and smooth muscle which causes vasodilation, inhibits platelet aggregation, and has anti-inflammatory, anti-thrombotic and anti-proliferative effects. In pulmonary arterial hypertension (PAH), PGI2 levels and PGI...See full text at original site
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引用元:
https://doi.org/10.1007/s40264-015-0365-x

データ提供:米国国立医学図書館(NLM)

Navigating the Labyrinth of Pulmonary Hypertension Treatment

Pulmonary arterial hypertension (PAH) is a complex and challenging disease, much like a labyrinthine desert with winding paths and hidden dangers. This study explores the intricate landscape of PAH treatment, focusing on the various prostacyclin (PGI2) analogues available to patients. Like a skilled cartographer mapping out a treacherous terrain, the authors provide a comprehensive overview of the pros and cons of each PGI2 analogue, helping clinicians navigate this complex treatment landscape.

A Journey Through the Desert of PAH Treatment

The study highlights the evolution of PGI2 analogue therapies, showcasing the remarkable progress made in treating PAH. Each analogue offers its own unique advantages and disadvantages, much like different pathways through a desert offer varying degrees of difficulty and reward. The authors emphasize the importance of choosing the most appropriate analogue based on individual patient needs and the specific challenges of their disease.

Finding the Oasis of Hope in PAH

While PGI2 analogues have significantly improved survival outcomes for PAH patients, the search for a truly effective oral analogue remains a priority. The development of such a therapy would be a breakthrough, much like finding a hidden oasis in the heart of the desert, offering a much-needed respite for patients. This study serves as a roadmap for future research, guiding scientists towards a more convenient and effective treatment for this complex disease.

Dr.Camel's Conclusion

This study, like a compass guiding travelers through the desert of PAH, provides valuable insights into the current state of PGI2 analogue therapies. While the search for an ideal treatment continues, the development of these analogues has significantly improved the lives of many patients. The authors' meticulous analysis of the pros and cons of each analogue serves as a vital resource for clinicians navigating the challenging terrain of PAH.

Date :
  1. Date Completed 2016-10-31
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

26748508

DOI: Digital Object Identifier

10.1007/s40264-015-0365-x

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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