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Effect of Vitamin D Receptor Activators on Glomerular Filtration Rate: A Meta-Analysis and Systematic Review.

Author: ChenJing, LiMing, ZhangQian, ZhangTiansong

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Administration of VDRAs increased serum creatinine levels. Subgroup analysis of studies that did not use SCr-based measures did not indicate a lower GFR in the VDRA group. Patients receiving VDRAs had lower eGFR (weighted mean difference WMD -1.29 mL/min /1.73 m2, 95% CI -2.42 to -0.17) and elevated serum creatinine (WMD 7.03 μmol/L, 95% CI 0.61 to 13.46).
Paper Details　
Original Abstract of the Article :
BACKGROUND: Vitamin D receptor activators (VDRAs) can protect against mineral bone disease, but they are reported to elevate serum creatinine (SCr) and may also reduce glomerular filtration rate (GFR). METHODS: We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727919/

データ提供：米国国立医学図書館（NLM）

The Effect of Vitamin D Receptor Activators on Kidney Function: A Meta-Analysis

We are all familiar with the importance of Vitamin D for strong bones, but did you know it plays a crucial role in kidney function too? This study dives into the world of vitamin D receptor activators (VDRAs) and their effects on kidney function, exploring the impact on glomerular filtration rate (GFR), a measure of kidney health. The researchers meticulously analyzed data from 31 clinical trials, revealing intriguing findings.

The authors employed a systematic review and meta-analysis, a scientific approach akin to sifting through the vast sands of the desert for precious gems of knowledge. Their investigation revealed that VDRAs, while beneficial for bone health, can indeed increase serum creatinine levels, a marker commonly used to assess kidney function. However, a deeper analysis of studies using alternative methods for measuring GFR showed no significant decrease in kidney function in the VDRA group. This discovery presents a fascinating conundrum: the mild increase in serum creatinine might not necessarily translate to a decline in kidney function.

More Research Needed to Determine the Significance of Increased Serum Creatinine

The researchers emphasize the need for further research using non-serum creatinine-based measures to fully understand the clinical significance of the observed increase in serum creatinine. This highlights the complexity of scientific exploration, where initial findings often lead to new questions and avenues for further investigation.

Dr. Camel's Conclusion

As a seasoned researcher who has traversed the vast expanses of scientific knowledge, I find this study's findings both intriguing and thought-provoking. The desert of scientific inquiry is filled with unexpected oases of knowledge, and this research reminds us that our understanding of complex biological systems is constantly evolving. It is imperative that we continue to explore the subtle nuances of vitamin D's role in kidney function to ensure optimal patient care.

Date :
  1. Date Completed 2016-07-20
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

26812502

DOI: Digital Object Identifier

PMC4727919

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