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Complex effects of inhibiting hepatic apolipoprotein B100 synthesis in humans.

Author: Dionizovick-DimanovskiMarija, Dionizovik-DimanovskiMarija, DonovanDaniel S, FontanezNelson, GinsbergHenry N, Hernandez-OnoAntonio, HolleranStephen, JimenezJhonsua, KarmallyWahida, MittlemanRobert S, MoonByoung, NgaiColleen, ObunikeJoseph, RamakrishnanRajasekhar, Reyes-SofferGissette, ThomasTiffany

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Mipomersen, an antisense oligonucleotide, effectively lowers LDL cholesterol by inhibiting apolipoprotein B synthesis. The study found that mipomersen reduced apoB in all lipoproteins without affecting VLDL secretion, potentially minimizing steatosis risk.
Paper Details　
Original Abstract of the Article :
Mipomersen is a 20mer antisense oligonucleotide (ASO) that inhibits apolipoprotein B (apoB) synthesis; its low-density lipoprotein (LDL)-lowering effects should therefore result from reduced secretion of very-low-density lipoprotein (VLDL). We enrolled 17 healthy volunteers who received placebo inje...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/26819195

データ提供：米国国立医学図書館（NLM）

Unveiling the Complexities of ApoB Inhibition: A New Perspective on Lipid Metabolism

This research delves into the intricate world of [lipid metabolism] and the effects of inhibiting [apolipoprotein B (apoB) synthesis]. The authors investigate the impact of [mipomersen], a [20mer antisense oligonucleotide (ASO)], on [lipoprotein] levels in [healthy volunteers]. Their study reveals unexpected findings, challenging conventional understanding of [apoB] regulation and highlighting the complex interplay of [lipid metabolism] pathways.

Mipomersen: A New Player in the Desert of Lipid Metabolism

The study reveals that [mipomersen] effectively reduces [apoB] levels in [VLDL], [IDL], and [LDL], but unexpectedly, it does not significantly affect the [production rates of VLDL apoB] and [VLDL triglycerides]. This intriguing observation suggests a more nuanced understanding of [apoB] regulation, highlighting the need for further exploration of [posttranscriptional] and [posttranslational] mechanisms.

Navigating the Desert of Lipid Metabolism: Understanding the Complexities of ApoB Regulation

The study’s findings underscore the complex nature of [lipid metabolism] and the need for a deeper understanding of the regulatory mechanisms involved. The unexpected findings regarding [mipomersen] provide valuable insights into the interplay of various factors that influence [lipoprotein] levels. This research serves as a reminder that the journey to understanding [lipid metabolism] is a continuous exploration, with new discoveries constantly shaping our understanding of these intricate pathways.

Dr.Camel's Conclusion

This study presents a compelling case for a more nuanced understanding of [apoB] regulation and the complex interplay of [lipid metabolism] pathways. The findings underscore the importance of further research into the mechanisms behind [apoB] regulation and the potential impact of inhibiting [apoB synthesis]. The desert of [lipid metabolism] is vast and intricate, and this research is a valuable step forward in our journey towards a more comprehensive understanding of these crucial pathways.

Date :
  1. Date Completed 2016-10-25
  2. Date Revised 2020-01-16
Further Info :

Pubmed ID

26819195

DOI: Digital Object Identifier

NIHMS796729

Related Literature

Article Analysis
・Effects of mipomersen injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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