Comparative Study of the Antioxidant Effects of Metformin, Glibenclamide, and Repaglinide in Alloxan-Induced Diabetic Rats.

Author: Chinwuba OkoyeTheophine, Chukwunonso ObiBonaventure, Nonye IgweChristiana, OkpashiVictor Eshu, Olisah AlumanahEdwin

Paper Details 
Original Abstract of the Article :
Diabetes mellitus is one of the serious global health problems affecting a significant proportion of both developed and developing countries. Overproduction of free radicals and oxidative stress has been associated with the development of diabetic complications. In the present study, the antioxidant...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707348/

データ提供:米国国立医学図書館(NLM)

Fighting Diabetes: The Antioxidant Power of Medications

Diabetes mellitus, a chronic metabolic disorder, affects millions worldwide. It's characterized by high blood sugar levels, often leading to complications affecting various organs. This research delves into the antioxidant effects of three commonly prescribed diabetes medications: metformin, glibenclamide, and repaglinide. The researchers investigated the impact of these medications on oxidative stress, a key player in the development of diabetic complications, in diabetic rats. The study found that all three medications exhibited significant antioxidant effects, demonstrating their potential in mitigating the damaging effects of oxidative stress on the body.

Understanding the Antioxidant Benefits of Diabetes Medications

This study provides valuable information about the potential of metformin, glibenclamide, and repaglinide in combating oxidative stress, a critical factor in diabetic complications. All three medications demonstrated significant antioxidant effects, reducing the levels of oxidative markers and improving the activity of antioxidant enzymes.

Keeping Oxidative Stress at Bay: A Healthy Lifestyle

While these medications can help manage oxidative stress, it's essential to maintain a healthy lifestyle to further minimize its effects. A balanced diet rich in fruits, vegetables, and whole grains, regular exercise, and managing stress can all contribute to a healthier body.

Dr. Camel's Conclusion

Just as a camel needs to conserve water in the harsh desert, managing diabetes requires a careful approach to combat oxidative stress. This research highlights the antioxidant potential of commonly prescribed diabetes medications, offering hope for mitigating the damaging effects of oxidative stress. Remember, a healthy lifestyle alongside appropriate medical care can help you navigate the journey of managing diabetes.
Date :
  1. Date Completed 2016-10-25
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

26824037

DOI: Digital Object Identifier

PMC4707348

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SNS
PICO Info
in preparation
Languages

English

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