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ITF2357 transactivates Id3 and regulate TGFβ/BMP7 signaling pathways to attenuate corneal fibrosis.

Author: BarathiVeluchamy A, ChaurasiaShyam S, LimRayne R, LiuYu-Chi, MehtaJodhbir S, MohanRajiv R, TanAlison

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

ITF2357, a histone deacetylase inhibitor, showed promise in reducing corneal fibrosis in a rabbit model. It decreased collagen expression and myofibroblast formation, suggesting its potential as an antifibrotic drug.
Paper Details　
Original Abstract of the Article :
Corneal fibrosis is often seen in patients with ocular trauma and infection that compromises corneal transparency resulting in vision loss. Treatment strategies including NSAIDs, steroids, MMC and corneal transplants have shown tremendous success but with several side effects and cellular toxicity. ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750002/

データ提供：米国国立医学図書館（NLM）

ITF2357: A Potential Anti-Fibrotic Drug for Corneal Fibrosis

This research delves into the challenging realm of corneal fibrosis, focusing on the potential of ITF2357, a histone deacetylase inhibitor (HDACi), as a novel therapeutic agent. The study investigated the safety, efficacy, and mechanism of action of ITF2357 in both in vitro and in vivo models of corneal fibrosis. The researchers discovered that ITF2357 significantly reduced collagen expression, myofibroblast formation, and corneal haze in a rabbit model of corneal fibrosis. Furthermore, the study revealed that ITF2357 exerted its anti-fibrotic effect by activating BMP7 levels and expressing Id3, a downstream target of TGFβ/BMP7 signaling pathways. These findings suggest that ITF2357 may offer a promising therapeutic strategy for treating corneal fibrosis.

A New Avenue for Treating Corneal Fibrosis

This research offers a potential new avenue for treating corneal fibrosis, a debilitating condition that can lead to vision loss. The study's findings suggest that ITF2357, a HDACi, may offer a safe and effective treatment option for corneal fibrosis. The study's findings provide valuable insights into the potential of this novel therapeutic agent and warrant further investigation.

Seeing Clearly

Corneal fibrosis can be a real obstacle to clear vision. This research offers hope that new treatments, like ITF2357, may offer effective solutions. It's a reminder that medical advancements can lead to new and potentially more effective treatments for a wide range of conditions, providing hope for a brighter future for those struggling with vision loss.

Dr.Camel's Conclusion

This study investigates the potential of ITF2357, a HDACi, as a novel therapeutic agent for treating corneal fibrosis. The study's findings suggest that ITF2357 may offer a safe and effective treatment option for corneal fibrosis, by reducing collagen expression, myofibroblast formation, and corneal haze. This research provides valuable insights into the potential of this novel therapeutic agent and warrants further investigation.

Date :
  1. Date Completed 2016-12-19
  2. Date Revised 2023-11-11
Further Info :

Pubmed ID

26865052

DOI: Digital Object Identifier

PMC4750002

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Languages

English

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