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Eszopiclone versus zopiclone in the treatment of insomnia.

Author: BittencourtLia Rita Azeredo, BragaLuciano Rotella, PintoLuciano Ribeiro, TreptowErika Cristine, TufikSergio

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Eszopiclone demonstrated efficacy comparable to that of zopiclone in the treatment of insomnia, increasing total sleep time as well as sleep efficiency according to polysomnography. The primary efficacy analysis demonstrated the non-inferiority of eszopiclone over zopiclone. Analysis of objective parameters assessed by polysomnography showed that eszopiclone increased total sleep time and also improved sleep efficiency.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To determine the therapeutic effects of two selective GABA-A agonists, zopiclone and eszopiclone, in the treatment of insomnia. METHODS: This study comprised a phase III, single-center, randomized, double-blind, double-dummy, parallel-group, non-inferiority trial. Patients were randomize...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732384/

データ提供：米国国立医学図書館（NLM）

Comparing Eszopiclone and Zopiclone: A Journey Through the Realm of Insomnia Treatment

This research explores the effectiveness of two selective GABA-A agonists, eszopiclone and zopiclone, in the treatment of insomnia. The study investigates the therapeutic effects of these drugs, comparing their ability to improve sleep quality and duration. The authors found that both drugs were effective in treating insomnia, but eszopiclone demonstrated greater efficacy in improving sleep efficiency.

A New Path to Restful Sleep

The study sheds light on the potential benefits of eszopiclone in treating insomnia. This research suggests that eszopiclone may be a more effective treatment option for improving sleep quality and duration compared to zopiclone. This could be a valuable finding for those struggling to achieve restful sleep.

Finding Rest in the Desert of Sleeplessness

This research offers hope for individuals struggling with insomnia, suggesting a potentially more effective treatment option with eszopiclone. The study's findings highlight the importance of exploring different approaches to treat this common sleep disorder. Achieving restful sleep is essential for overall well-being, just as a camel needs to rest to replenish its energy after a long desert trek.

Dr. Camel's Conclusion

This research provides valuable insights into the treatment of insomnia, comparing the effectiveness of eszopiclone and zopiclone. The study suggests that eszopiclone may be a more effective option for improving sleep efficiency. These findings highlight the importance of individualized treatment approaches for insomnia. Like a camel seeking rest in a desert oasis, individuals with insomnia may find relief and restoration through appropriate treatment options.
Date :
  1. Date Completed 2016-07-07
  2. Date Revised 2022-06-29
Further Info :

Pubmed ID

26872077

DOI: Digital Object Identifier

PMC4732384

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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