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Incorporating Biomarkers in Studies of Chemoprevention.

Author: FabianCarol J, KimlerBruce F

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Tamoxifen and raloxifene are FDA-approved for breast cancer prevention, but only 4% of eligible women use them due to side effects and lack of survival benefits. Research now focuses on better risk prediction, behavioral interventions, and new trial designs using biomarkers to identify at-risk women and predict drug effectiveness.
Paper Details　
Original Abstract of the Article :
Despite Food and Drug Administration approval of tamoxifen and raloxifene for breast cancer risk reduction and endorsement by multiple agencies, uptake of these drugs for primary prevention in the United States is only 4% for risk eligible women likely to benefit from their use. Side effects coupled...See full text at original site
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引用元：
https://doi.org/10.1007/978-3-319-22909-6_3

データ提供：米国国立医学図書館（NLM）

The Power of Biomarkers in Chemoprevention Research

Chemoprevention, the use of drugs or dietary interventions to prevent cancer, is a promising approach to reducing cancer risk. This review delves into the crucial role of biomarkers in chemoprevention research, exploring how these biological markers can enhance our understanding of cancer risk, guide treatment strategies, and facilitate the development of more effective preventive interventions.

Biomarkers: Guiding the Path to Cancer Prevention

The review highlights the increasing importance of biomarkers in refining cancer risk assessment and selecting cohorts for chemoprevention trials. Biomarkers also play a vital role in evaluating the efficacy of preventive interventions, particularly in early-phase trials. By measuring changes in biomarkers, researchers can gain valuable insights into the mechanisms of action of potential chemopreventive agents and identify those most likely to be effective.

A New Era of Personalized Cancer Prevention

This review underscores the transformative potential of biomarkers in advancing the field of chemoprevention. By integrating biomarkers into research and clinical practice, we can move towards a more personalized approach to cancer prevention, tailoring interventions to individual risk factors and promoting more effective and targeted strategies for preventing cancer.

Dr.Camel's Conclusion

This review is like a compass guiding us through the vast desert of cancer prevention research. Biomarkers, like the stars in the night sky, provide crucial insights into cancer risk and the effectiveness of preventive interventions, enabling us to navigate this complex field and develop more effective and personalized strategies for cancer prevention.

Date :
  1. Date Completed 2016-08-10
  2. Date Revised 2016-11-09
Further Info :

Pubmed ID

26987531

DOI: Digital Object Identifier

10.1007/978-3-319-22909-6_3

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・Side Effects of raloxifene
SNS
PICO Info
in preparation
Languages

English

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