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The adrenal specific toxicant mitotane directly interacts with lipid membranes and alters membrane properties depending on lipid composition.

Author: HaralampievIvan, HusterDaniel, KroissMatthias, MüllerPeter, SbieraSilviu, ScheidtHolger A, SchirbelAndreas, TheisgenStephan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that mitotane, a drug used to treat adrenocortical carcinoma, interacts with lipid membranes, causing disturbances in bilayer structure and increased membrane permeability. This may contribute to the drug's effects and side effects.
Paper Details　
Original Abstract of the Article :
Mitotane (o,p'.-DDD) is an orphan drug approved for the treatment of adrenocortical carcinoma. The mechanisms, which are responsible for this activity of the drug, are not completely understood. It can be hypothesized that an impact of mitotane is mediated by the interaction with cellular membranes....See full text at original site
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引用元：
https://doi.org/10.1016/j.mce.2016.03.022

データ提供：米国国立医学図書館（NLM）

The Complex Dance of Mitotane and Cellular Membranes

This research delves into the intricate world of cellular membranes, specifically investigating the interaction of mitotane, a drug used for treating adrenocortical carcinoma, with these vital structures. The authors, akin to expert mapmakers charting a new territory, employed a range of biophysical techniques to unravel the relationship between mitotane and lipid membranes.

Unveiling the Impact of Mitotane on Membrane Structure

The research revealed that mitotane and its main metabolite, o,p'-DDA, bind to lipid membranes by inserting themselves into the lipid-water interface. This insertion disrupts the membrane's delicate structure, leading to increased permeability, much like a sudden sandstorm creating gaps in a desert landscape.

Navigating the Terrain of Cell Membranes

The study's findings highlight the importance of understanding how drugs interact with cellular membranes. This knowledge is crucial for developing safer and more effective treatments, akin to carefully navigating a desert to avoid treacherous terrain. For example, it emphasizes the need to consider the specific lipid composition of membranes when designing therapies, as this can influence the drug's effectiveness and potential side effects.

Dr.Camel's Conclusion

Mitotane's interaction with cellular membranes is a complex dance. This research helps us understand the choreography, revealing how the drug's presence can disrupt the delicate balance of these vital structures. This knowledge is crucial for guiding the development of targeted therapies that effectively combat disease while minimizing potential side effects.

Date :
  1. Date Completed 2017-10-06
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

27002491

DOI: Digital Object Identifier

10.1016/j.mce.2016.03.022

Related Literature

Article Analysis
・Side Effects of mitotane
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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