Tasimelteon: A Review in Non-24-Hour Sleep-Wake Disorder in Totally Blind Individuals.

Author: KeatingGillian M

Paper Details 
Original Abstract of the Article :
Tasimelteon (Hetlioz(®)) is a dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (Non-24) (free-running disorder). In two randomized, double-masked, multicentre, phase III trials, totally blind individuals with Non-24 who received oral tasimelteon 20 mg on...See full text at original site
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引用元:
https://doi.org/10.1007/s40263-016-0330-y

データ提供:米国国立医学図書館(NLM)

Tasimelteon: A Treatment for Non-24-Hour Sleep-Wake Disorder

This research explores the fascinating world of sleep medicine, specifically focusing on the treatment of non-24-hour sleep-wake disorder (Non-24), a circadian rhythm disorder affecting individuals with total blindness. The authors investigate the efficacy of tasimelteon, a dual melatonin receptor agonist, in treating Non-24. The study reviews the results of two phase III clinical trials that evaluated the effectiveness of tasimelteon in entraining and maintaining the circadian pacemaker in totally blind individuals with Non-24. The findings indicate that tasimelteon is effective in treating Non-24, improving sleep/wake parameters and overall functioning.

The Impact of Tasimelteon on Non-24 Treatment

This study highlights the significant impact of tasimelteon in treating Non-24, a challenging circadian rhythm disorder affecting individuals with total blindness. The authors' findings demonstrate that tasimelteon is effective in entraining and maintaining the circadian pacemaker, leading to improvements in sleep quality and overall functioning. This research is a valuable contribution to the field of sleep medicine, offering a new and effective treatment option for individuals with Non-24.

The Importance of Understanding Circadian Rhythms

This research underscores the importance of understanding and managing circadian rhythms, particularly in individuals with sleep disorders. Non-24 is a complex condition that can significantly impact quality of life. The study's findings demonstrate the effectiveness of tasimelteon in addressing this disorder, offering a glimmer of hope for individuals struggling with persistent sleep disruption. As we continue to explore the intricacies of sleep and circadian rhythms, we can develop more effective and targeted treatments to improve sleep quality and overall well-being for individuals with a variety of sleep disorders.

Dr.Camel's Conclusion

As a researcher who has spent countless hours studying the intricate workings of the human body, I am always fascinated by the power of our internal clocks. This research highlights the significant impact of circadian rhythm disorders like Non-24, and the importance of developing effective treatments to address these conditions. The study's findings offer hope for individuals with Non-24, providing a new and effective treatment option that can improve their quality of life. I am optimistic about the future of sleep medicine, and I believe that continued research and innovation will lead to a future where everyone has access to the sleep they need to live healthy and fulfilling lives.
Date :
  1. Date Completed 2017-04-13
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

27003694

DOI: Digital Object Identifier

10.1007/s40263-016-0330-y

Related Literature

SNS
PICO Info
in preparation
Languages

English

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