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5-Aminosalicylic acid derivatives. Clinical and pharmaceutical evaluation.

Author: ChristensenL A, JacobsenB A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

New 5-aminosalicylic acid (5-ASA) derivatives, such as Balsalazide and Dipentum, are as effective as salazosulphapyridine (SASP) in treating ulcerative colitis with fewer side effects. Controlled-release preparations are promising for maintaining remission and treating mild to moderate flares in ulcerative colitis.
Paper Details　
Original Abstract of the Article :
Several new 5-aminosalicylic acid (5-ASA) derivatives have been introduced for the treatment of chronic inflammatory bowel disease (CIBD). In azo-bond preparations, 5-ASA is linked to an inert carrier (Balsalazide) or to another 5-ASA molecule (Dipentum). The pharmacokinetic profile is similar to sa...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2702310

データ提供：米国国立医学図書館（NLM）

5-Aminosalicylic Acid Derivatives: A New Oasis in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), like a persistent desert sandstorm, can wreak havoc on the digestive system. This study explores the clinical and pharmaceutical evaluation of several new 5-aminosalicylic acid (5-ASA) derivatives, promising treatment options for IBD, like finding a source of relief in the midst of the desert storm.

5-ASA Derivatives: A Promising Treatment for IBD

The study highlights the effectiveness and safety of various 5-ASA derivatives in treating chronic inflammatory bowel disease (CIBD). The findings suggest that these drugs offer a valuable alternative to salazosulphapyridine (SASP), reducing side effects while maintaining similar efficacy. The study explores the different formulations of 5-ASA derivatives, including azo-bond and controlled-release preparations, providing insights into the pharmacokinetic profiles and therapeutic benefits of each approach.

Navigating the Desert of Inflammatory Bowel Disease

This study offers a glimpse into the promising landscape of 5-ASA derivatives, providing hope for individuals struggling with inflammatory bowel disease. The findings highlight the value of these drugs in managing IBD symptoms and minimizing side effects, offering a potential oasis in the desert of this chronic illness.

Dr.Camel's Conclusion

The study explores the potential of 5-ASA derivatives as a valuable treatment option for inflammatory bowel disease. These drugs offer a glimmer of hope for individuals navigating the challenging landscape of IBD, much like finding a spring of fresh water in a dry and barren desert.
Date :
  1. Date Completed 1990-11-19
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2702310

DOI: Digital Object Identifier

2702310

Related Literature

Article Analysis
・Side Effects of balsalazide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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