The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology.

Author: BelardinelliLuiz, BraunInga, DannerBernhard C, DobrevDobromir, FischerThomas H, FreyNorbert, GummertJan, HartmannNico, HasenfussGerd, MaierLars S, MasonFleur E, PabelSteffen, RennerAndré, SchotolaHanna, SossallaSamuel, VoigtNiels

Paper Details 
Original Abstract of the Article :
Pharmacological rhythm control of atrial fibrillation (AF) in patients with structural heart disease is limited. Ranolazine in combination with low dose dronedarone remarkably reduced AF-burden in the phase II HARMONY trial. We thus aimed to investigate the possible mechanisms underlying these resul...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.yjmcc.2016.03.012

データ提供:米国国立医学図書館(NLM)

Investigating the Synergistic Effects of Ranolazine and Dronedarone for Atrial Fibrillation Management

The field of [cardiology] is constantly seeking new ways to manage [atrial fibrillation], a common heart rhythm disorder. This study delves into the potential benefits of combining [ranolazine] and [dronedarone] for patients with [structural heart disease]. Building upon the promising results of the [HARMONY trial], researchers aim to uncover the mechanisms underlying the effectiveness of this drug combination. By investigating the electrophysiological effects of [ranolazine] and [dronedarone], the authors seek to provide a deeper understanding of how these medications work together to control [atrial fibrillation] and improve patient outcomes.

Potential for Improved Rhythm Control in Atrial Fibrillation

The study explores the potential of combining [ranolazine] and [dronedarone] to achieve better rhythm control in patients with [atrial fibrillation]. This combination therapy might offer a valuable alternative for patients who haven't responded well to other treatment options. Further research is needed to confirm the long-term efficacy and safety of this combination therapy.

Maintaining Heart Health: Understanding Atrial Fibrillation

It's important to be aware of the potential risks associated with [atrial fibrillation], a heart rhythm disorder that can lead to complications like [stroke]. Maintaining a healthy lifestyle, including [regular exercise] and [a balanced diet], and seeking prompt medical attention for any concerning symptoms can help prevent or manage [atrial fibrillation]. Just as a camel adapts to survive in a desert environment, we must learn to understand and care for our hearts, ensuring their optimal function.

Dr.Camel's Conclusion

This research offers valuable insights into the potential of combining [ranolazine] and [dronedarone] for the management of [atrial fibrillation]. Further investigation is crucial to fully understand the benefits and risks associated with this combination therapy. This study reminds us that the quest for effective treatments for heart rhythm disorders is an ongoing journey, demanding continual exploration and innovation.

Date :
  1. Date Completed 2017-05-31
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27056421

DOI: Digital Object Identifier

10.1016/j.yjmcc.2016.03.012

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.