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Object recognition impairment and rescue by a dopamine D2 antagonist in hyperdopaminergic mice.
Author: FrançaArthur S C, Lobão-SoaresBruno, MuratoriLarissa, NascimentoGeorge Carlos, PereiraCatia Mendes, RibeiroSidarta
Original Abstract of the Article :
Genetically-modified mice without the dopamine transporter (DAT) are hyperdopaminergic, and serve as models for studies of addiction, mania and hyperactive disorders. Here we investigated the capacity for object recognition in mildly hyperdopaminergic mice heterozygous for DAT (DAT +/-), with synapt...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.bbr.2016.04.009
データ提供:米国国立医学図書館(NLM)
Object Recognition Impairment and Rescue by Dopamine D2 Antagonist
This study investigates the role of dopamine in cognitive function, particularly in the context of object recognition. The study uses genetically modified mice with altered dopamine levels to examine the impact of dopamine dysregulation on object recognition memory.
Dopamine’s Impact on Object Recognition: A Delicate Balance
The researchers demonstrate that a mild increase in dopamine levels can impair object recognition, while a low dose of a dopamine D2 antagonist can restore normal object recognition. This finding suggests that the level of dopamine activity plays a critical role in object recognition, highlighting the need for a delicate balance to ensure optimal cognitive function.
Understanding Cognitive Processes: A Molecular Perspective
This study provides valuable insights into the molecular mechanisms underlying cognitive function, particularly object recognition. It underscores the importance of dopamine signaling in mediating cognitive processes and highlights the potential of targeting specific dopamine receptors to improve cognitive function in individuals with dopamine-related cognitive impairments. The study encourages further research to elucidate the precise role of dopamine in various cognitive processes.
Dr.Camel's Conclusion
Just as a camel navigates the desert using its keen senses and innate survival instincts, our brains rely on a delicate balance of neurochemicals, including dopamine, to guide our cognitive processes. This study helps us to better understand the intricate interplay between dopamine and cognition, offering valuable insights into the mechanisms underlying memory and learning.
Date :
- Date Completed 2017-11-21
- Date Revised 2019-12-10
Further Info :
Related Literature
English
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