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Current Pharmacologic Therapy for Nonalcoholic Fatty Liver Disease.

Author: GaneshSwaytha, RustgiVinod K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Nonalcoholic steatohepatitis (NASH) can be improved with weight loss, exercise, and diet modification. Other therapies target insulin resistance, oxidative stress, cytoprotection, and fibrosis. Insulin sensitizers and vitamin E show promise but have side effects. No single treatment is universally effective. Further research on existing and potential drugs is needed.
Paper Details　
Original Abstract of the Article :
Weight loss, regular exercise, and diet composition modification seem to improve biochemical and histologic abnormalities. Other therapies directed at insulin resistance, oxidative stress, cytoprotection, and fibrosis may also offer benefits. Insulin sensitizers and vitamin E seem to be the most pro...See full text at original site
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引用元：
https://doi.org/10.1016/j.cld.2015.10.009

データ提供：米国国立医学図書館（NLM）

Nonalcoholic Fatty Liver Disease: A Journey Through the Shifting Sands of Treatment Options

The field of liver disease research is constantly evolving, seeking effective treatments for the growing prevalence of nonalcoholic fatty liver disease (NAFLD). This research provides an overview of current pharmacologic therapies for NAFLD, highlighting the challenges and potential avenues for improvement. While lifestyle modifications, such as weight loss, regular exercise, and dietary changes, are considered the mainstay of treatment, pharmacologic interventions aimed at addressing insulin resistance, oxidative stress, and fibrosis are also being explored. However, the current lack of universally applicable treatments and the presence of side effects necessitate further research and development of new therapies.

Navigating the Desert of NAFLD: A Multifaceted Approach

The complexities of NAFLD are vast, resembling the shifting sands of a desert. Effective management requires a multifaceted approach that considers individual factors, lifestyle modifications, and potential pharmacologic interventions. While current treatments have shown some benefits, the lack of universally applicable therapies highlights the need for ongoing research and development of new and innovative solutions.

A Healthy Oasis in the Desert of Liver Disease: Embracing Lifestyle Modifications

While the search for effective pharmacologic treatments for NAFLD continues, embracing healthy lifestyle choices can play a significant role in managing the disease. Maintaining a healthy weight, engaging in regular physical activity, and adopting a balanced diet can help reduce the risk of NAFLD progression and improve overall liver health. Consulting with a healthcare professional is essential for personalized advice and guidance on navigating this journey.

Dr. Camel's Conclusion

The journey through the desert of NAFLD is demanding, requiring a multifaceted approach to treatment. While lifestyle modifications are paramount, ongoing research is crucial to develop effective pharmacologic therapies. This research emphasizes the need for continuous exploration and innovation in the field of liver disease, striving to find new avenues for preventing and managing this complex condition.

Date :
  1. Date Completed 2017-01-16
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

27063274

DOI: Digital Object Identifier

10.1016/j.cld.2015.10.009

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English

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