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Effect of Ambrisentan on Exercise Capacity in Adult Patients After the Fontan Procedure.

Author: CedarsAri M, CogganAndrew R, KempDebra, LudbrookPhilip A, NovakEric L, PetersonLinda R, SaefJoshua

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Abrisentan, an endothelin receptor antagonist, was studied for its effects on exercise capacity in adults with Fontan circulation. It improved peak oxygen consumption and decreased the slope of the ventilatory equivalent ratio for oxygen. Abrisentan was well-tolerated.
Paper Details　
Original Abstract of the Article :
The Fontan operation is a common end point for children born with a single functional ventricle. Fontan patients typically experience physiological deterioration leading to transplant or death in their third or fourth decades of life. This deterioration is partially attributable to progressive incre...See full text at original site
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引用元：
https://doi.org/10.1016/j.amjcard.2016.02.024

データ提供：米国国立医学図書館（NLM）

Enhancing Exercise Capacity in Fontan Patients: A Study of Ambrisentan Therapy

This study focuses on the challenges faced by patients who have undergone the Fontan procedure, a complex surgical intervention for single-ventricle heart defects. It's like studying the resilience of desert plants, adapting to harsh conditions and seeking ways to thrive.

The researchers are investigating the potential benefits of ambrisentan, an endothelin receptor antagonist, for improving exercise capacity in Fontan patients. They aim to find ways to mitigate the physical limitations often experienced by these individuals, much like desert nomads seeking to conquer challenging terrains.

This research offers hope for Fontan patients, providing potential avenues for improving their quality of life and increasing their physical capabilities. It's a testament to the ongoing quest for innovative treatments that address the specific needs of patients.

The Potential of Ambrisentan for Improving Exercise Capacity

The study suggests that ambrisentan can improve peak oxygen consumption and other exercise parameters in Fontan patients, offering a potential approach to enhancing their physical capabilities. It's like finding a source of energy in the desert, empowering individuals to overcome physical limitations.

A Step Towards Improved Quality of Life for Fontan Patients

This research highlights the importance of personalized medicine, seeking to tailor treatment approaches to meet the unique needs of individual patients. It's a reminder that the journey of healthcare is not a one-size-fits-all approach but a journey of discovery and adaptation.

Dr. Camel's Conclusion

This study underscores the importance of ongoing research and innovation in the field of cardiovascular care. It highlights the potential for new treatments to improve the quality of life for patients with complex heart conditions. It's a reminder that even in the face of seemingly insurmountable challenges, there is always hope for progress and improvement.

Date :
  1. Date Completed 2016-08-22
  2. Date Revised 2016-11-26
Further Info :

Pubmed ID

27063478

DOI: Digital Object Identifier

10.1016/j.amjcard.2016.02.024

Related Literature

Article Analysis
・Side Effects of ambrisentan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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