Paper Details

  1. Home
  2. Paper Details

Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use.

Author: MatsumotoRae R, PopeLaura E, SiffertJoao, TaylorCharles P, TraynelisStephen F

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review summarizes the interactions of dextromethorphan (DM) with brain receptors and transporters, considering its metabolic and pharmacokinetic properties. The review suggests that DM/Q, a combination of DM and quinidine, inhibits serotonin and norepinephrine reuptake, blocks NMDA receptors, and may antagonize nicotinic acetylcholine receptors and activate sigma-1 receptors.
Paper Details　
Original Abstract of the Article :
Dextromethorphan (DM) has been used for more than 50years as an over-the-counter antitussive. Studies have revealed a complex pharmacology of DM with mechanisms beyond blockade of N-methyl-d-aspartate (NMDA) receptors and inhibition of glutamate excitotoxicity, likely contributing to its pharmacolog...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.pharmthera.2016.04.010

データ提供：米国国立医学図書館（NLM）

Dextromethorphan's Complex Pharmacology: Unveiling Its Therapeutic Potential

The [antitussive] drug [dextromethorphan] has been used for decades, but its [pharmacological mechanisms] remain a subject of ongoing research. This review explores the [complex pharmacology] of [dextromethorphan] and its [potential clinical applications]. The authors discuss the [various mechanisms of action] of [dextromethorphan], including its effects on [brain receptors and transporters] and its [metabolic properties]. The development of the [dextromethorphan/quinidine (Nuedexta®)] combination for the treatment of [pseudobulbar affect] has renewed interest in understanding the [therapeutic potential] of [dextromethorphan].

Dextromethorphan: A Multifaceted Therapeutic

The review's findings highlight the [multifaceted nature] of [dextromethorphan] and its potential to act on [multiple targets] in the brain. The authors' analysis of the [interaction of dextromethorphan with brain receptors and transporters] provides a comprehensive understanding of its [pharmacological profile]. This knowledge is crucial for developing [effective and targeted treatments] using [dextromethorphan] for various conditions, including [pseudobulbar affect] and potentially [other neurological disorders].

The Future of Dextromethorphan Therapy

This review provides a valuable resource for understanding the [complex pharmacology] of [dextromethorphan] and its [potential clinical applications]. The authors' discussion of [dextromethorphan's interactions with brain receptors and transporters] and its [metabolic properties] paves the way for [further research] into the use of [dextromethorphan] in treating a wide range of conditions. Continued research in this area could lead to the development of [new and effective therapies] based on this versatile drug.

Dr.Camel's Conclusion

Just like the desert holds hidden treasures beneath its surface, [dextromethorphan] holds hidden therapeutic potential beyond its traditional use as an antitussive. This review encourages us to delve deeper into the complex pharmacology of this fascinating drug.

Date :
  1. Date Completed 2017-07-31
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

27139517

DOI: Digital Object Identifier

10.1016/j.pharmthera.2016.04.010

Related Literature

Article Analysis
・Effects of dextromethorphan and quinidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.